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Plumbagin Ameliorates CCl4-Induced Hepatic Fibrosis in Rats via the Epidermal Growth Factor Receptor Signaling Pathway
Joint Authors
Chen, Si
Chen, Yi
Chen, Bi
Cai, Yi-jing
Zou, Zhuo-lin
Wang, Jin-guo
Lin, Zhuo
Wang, Xiao-dong
Fu, Li-yun
Hu, Yao-ren
Chen, Yong-ping
Chen, Da-zhi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Epidermal growth factor (EGF) and its signaling molecules, EGFreceptor (EGFR) and signal transducer and activator of transcription factor 3 (STAT3), have been considered to play a role in liver fibrosis and cirrhosis.
Plumbagin (PL) is an extracted component from the plant and has been used to treat different kinds of cancer.
However, its role in regulation of EGFR and STAT3 during liver fibrosis has not been investigated.
In this study, the effects of PL on the regulation of EGFR and STAT3 were investigated in carbon tetrachloride (CCl4) induced liver fibrosis and hepatic stellate cells (HSC-T6).
PL significantly attenuated liver injury and fibrosis in CCl4 treated rats.
At concentrations of 2 to 6 μM, PL did not induce significant cytotoxicity of HSC-T6 cells.
Moreover, PL reduced phosphorylation of EGFR and STAT3 in both fibrotic liver and heparin-binding EGF-like growth factor (HB-EGF) treated HSC-T6 cells.
Furthermore, PL reduced the expression of α-SMA, EGFR, and STAT3 in both fibrotic liver and HB-EGF treated HSC-T6 cells.
In conclusion, plumbagin could ameliorate the development of hepatic fibrosis through its downregulation of EGFR and STAT3 in the liver, especially in hepatic stellate cells.
American Psychological Association (APA)
Chen, Si& Chen, Yi& Chen, Bi& Cai, Yi-jing& Zou, Zhuo-lin& Wang, Jin-guo…[et al.]. 2015. Plumbagin Ameliorates CCl4-Induced Hepatic Fibrosis in Rats via the Epidermal Growth Factor Receptor Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063426
Modern Language Association (MLA)
Chen, Si…[et al.]. Plumbagin Ameliorates CCl4-Induced Hepatic Fibrosis in Rats via the Epidermal Growth Factor Receptor Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1063426
American Medical Association (AMA)
Chen, Si& Chen, Yi& Chen, Bi& Cai, Yi-jing& Zou, Zhuo-lin& Wang, Jin-guo…[et al.]. Plumbagin Ameliorates CCl4-Induced Hepatic Fibrosis in Rats via the Epidermal Growth Factor Receptor Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063426
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063426