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Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s)
المؤلفون المشاركون
Gutierres, Vânia Ortega
Campos, Michel Leandro
Arcaro, Carlos Alberto
Assis, Renata Pires
Baldan-Cimatti, Helen Mariana
Peccinini, Rosângela Gonçalves
Paula-Gomes, Silvia
Kettelhut, Isis Carmo
Baviera, Amanda Martins
Brunetti, Iguatemy Lourenço
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-03
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
This study measures the curcumin concentration in rat plasma by liquid chromatography and investigates the changes in the glucose tolerance and insulin sensitivity of streptozotocin-diabetic rats treated with curcumin-enriched yoghurt.
The analytical method for curcumin detection was linear from 10 to 500 ng/mL.
The Cmax and the time to reach Cmax (tmax) of curcumin in plasma were 3.14 ± 0.9 μg/mL and 5 minutes (10 mg/kg, i.v.) and 0.06 ± 0.01 μg/mL and 14 minutes (500 mg/kg, p.o.).
The elimination half-time was 8.64 ± 2.31 (i.v.) and 32.70 ± 12.92 (p.o.) minutes.
The oral bioavailability was about 0.47%.
Changes in the glucose tolerance and insulin sensitivity were investigated in four groups: normal and diabetic rats treated with yoghurt (NYOG and DYOG, resp.) and treated with 90 mg/kg/day curcumin incorporated in yoghurt (NC90 and DC90, resp.).
After 15 days of treatment, the glucose tolerance and the insulin sensitivity were significantly improved in DC90 rats in comparison with DYOG, which can be associated with an increase in the AKT phosphorylation levels and GLUT4 translocation in skeletal muscles.
These findings can explain, at least in part, the benefits of curcumin-enriched yoghurt to diabetes and substantiate evidences for the curcumin metabolite(s) as being responsible for the antidiabetic activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gutierres, Vânia Ortega& Campos, Michel Leandro& Arcaro, Carlos Alberto& Assis, Renata Pires& Baldan-Cimatti, Helen Mariana& Peccinini, Rosângela Gonçalves…[et al.]. 2015. Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s). Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1063453
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gutierres, Vânia Ortega…[et al.]. Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s). Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1063453
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gutierres, Vânia Ortega& Campos, Michel Leandro& Arcaro, Carlos Alberto& Assis, Renata Pires& Baldan-Cimatti, Helen Mariana& Peccinini, Rosângela Gonçalves…[et al.]. Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s). Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1063453
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063453
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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