Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s)
Joint Authors
Gutierres, Vânia Ortega
Campos, Michel Leandro
Arcaro, Carlos Alberto
Assis, Renata Pires
Baldan-Cimatti, Helen Mariana
Peccinini, Rosângela Gonçalves
Paula-Gomes, Silvia
Kettelhut, Isis Carmo
Baviera, Amanda Martins
Brunetti, Iguatemy Lourenço
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
This study measures the curcumin concentration in rat plasma by liquid chromatography and investigates the changes in the glucose tolerance and insulin sensitivity of streptozotocin-diabetic rats treated with curcumin-enriched yoghurt.
The analytical method for curcumin detection was linear from 10 to 500 ng/mL.
The Cmax and the time to reach Cmax (tmax) of curcumin in plasma were 3.14 ± 0.9 μg/mL and 5 minutes (10 mg/kg, i.v.) and 0.06 ± 0.01 μg/mL and 14 minutes (500 mg/kg, p.o.).
The elimination half-time was 8.64 ± 2.31 (i.v.) and 32.70 ± 12.92 (p.o.) minutes.
The oral bioavailability was about 0.47%.
Changes in the glucose tolerance and insulin sensitivity were investigated in four groups: normal and diabetic rats treated with yoghurt (NYOG and DYOG, resp.) and treated with 90 mg/kg/day curcumin incorporated in yoghurt (NC90 and DC90, resp.).
After 15 days of treatment, the glucose tolerance and the insulin sensitivity were significantly improved in DC90 rats in comparison with DYOG, which can be associated with an increase in the AKT phosphorylation levels and GLUT4 translocation in skeletal muscles.
These findings can explain, at least in part, the benefits of curcumin-enriched yoghurt to diabetes and substantiate evidences for the curcumin metabolite(s) as being responsible for the antidiabetic activity.
American Psychological Association (APA)
Gutierres, Vânia Ortega& Campos, Michel Leandro& Arcaro, Carlos Alberto& Assis, Renata Pires& Baldan-Cimatti, Helen Mariana& Peccinini, Rosângela Gonçalves…[et al.]. 2015. Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s). Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1063453
Modern Language Association (MLA)
Gutierres, Vânia Ortega…[et al.]. Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s). Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1063453
American Medical Association (AMA)
Gutierres, Vânia Ortega& Campos, Michel Leandro& Arcaro, Carlos Alberto& Assis, Renata Pires& Baldan-Cimatti, Helen Mariana& Peccinini, Rosângela Gonçalves…[et al.]. Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s). Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1063453
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063453