Anticancer Activity of Saponins from Allium chinense against the B16 Melanoma and 4T1 Breast Carcinoma Cell
المؤلفون المشاركون
Xia, Liqiu
Yu, Zhihui
Zhang, Tong
Zhou, Fengjuan
Xiao, Xiuqing
He, Hao
Rang, Jie
Quan, Meifang
Wang, Ting
Zuo, Mingxing
Ding, Xuezhi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The cytotoxic substance of A.
chinense saponins (ACSs) was isolated using ethanol extraction and purified with the D101 macroporous adsorption resin approach.
We investigated the anticancer activity of ACSs in the B16 melanoma and 4T1 breast carcinoma cell lines.
Methylthioninium chloride and hematoxylin-eosin staining with Giemsa dyestuff were used when the cells were treated with ACSs.
The results showed that the cells morphologies changed significantly; ACSs induced cell death in B16 and 4T1 cells based on acridine orange/ethidium bromide double fluorescence staining, with the number and degree of apoptotic tumor cells increasing as ACS concentration increased.
ACSs inhibited the proliferation of B16 and 4T1 cells in a dose-dependent manner.
They also inhibited cell migration and colony formation and exhibited a concentration-dependent effect.
In addition, ACSs apparently inhibited the growth of melanoma in vivo.
The preliminary antitumor in vivo assay revealed that early medication positively affected tumor inhibition action and effectively protected the liver and spleen of C57 BL/6 mice from injury.
This study provides evidence for the cytotoxicity of ACSs and a strong foundation for further research to establish the theoretical basis for cell death and help in the design and development of new anticancer drugs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Zhihui& Zhang, Tong& Zhou, Fengjuan& Xiao, Xiuqing& Ding, Xuezhi& He, Hao…[et al.]. 2015. Anticancer Activity of Saponins from Allium chinense against the B16 Melanoma and 4T1 Breast Carcinoma Cell. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063499
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Zhihui…[et al.]. Anticancer Activity of Saponins from Allium chinense against the B16 Melanoma and 4T1 Breast Carcinoma Cell. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1063499
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Zhihui& Zhang, Tong& Zhou, Fengjuan& Xiao, Xiuqing& Ding, Xuezhi& He, Hao…[et al.]. Anticancer Activity of Saponins from Allium chinense against the B16 Melanoma and 4T1 Breast Carcinoma Cell. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063499
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063499
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر