A Bio-Guided Fractionation to Assess the Inhibitory Activity of Calendula officinalis L. on the NF-κB Driven Transcription in Human Gastric Epithelial Cells
المؤلفون المشاركون
D’Ambrosio, Michele
Bosisio, Enrica
Ciocarlan, Alexandru
Fumagalli, Marco
Guerriero, Antonio
Harghel, Petru
Dell'Agli, Mario
Colombo, Elisa
Sangiovanni, Enrico
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-28
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Calendula officinalis L.
has been largely known for its topical anti-inflammatory properties; however, there are no experimental evidences about its antiphlogistic effect at the gastric level.
To investigate whether marigold might exert an activity against gastric inflammation, a CH2Cl2 extract obtained from C.
officinalis flowers was evaluated in vitro on the NF-κB pathway.
The lipophilic extract demonstrated a significant inhibitory effect on the NF-κB driven transcription.
The identification of active compounds was conducted by a bio-guided fractionation of the extract that afforded 16 fractions.
Fraction J exhibited a concentration-dependent inhibitory activity on the NF-κB driven transcription and significantly contributed to the antiphlogistic effect showed by CH2Cl2 extract.
The main components of fraction J were loliolide and the fucoside acetates of β-eudesmol and viridiflorol.
HPLC analysis of fractions D and E led to the identification and isolation of triterpene esters that showed a concentration-dependent inhibition of the NF-κB driven transcription, with faradiol-3-myristate and the corresponding aglycone being the most active compounds.
The present study provides some experimental evidences that Calendula officinalis L.
may exert an anti-inflammatory activity on the gastric district by the inhibition of the NF-κB system, identifying the compounds responsible, at least in part, for the observed effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Colombo, Elisa& Sangiovanni, Enrico& D’Ambrosio, Michele& Bosisio, Enrica& Ciocarlan, Alexandru& Fumagalli, Marco…[et al.]. 2015. A Bio-Guided Fractionation to Assess the Inhibitory Activity of Calendula officinalis L. on the NF-κB Driven Transcription in Human Gastric Epithelial Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063503
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Colombo, Elisa…[et al.]. A Bio-Guided Fractionation to Assess the Inhibitory Activity of Calendula officinalis L. on the NF-κB Driven Transcription in Human Gastric Epithelial Cells. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063503
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Colombo, Elisa& Sangiovanni, Enrico& D’Ambrosio, Michele& Bosisio, Enrica& Ciocarlan, Alexandru& Fumagalli, Marco…[et al.]. A Bio-Guided Fractionation to Assess the Inhibitory Activity of Calendula officinalis L. on the NF-κB Driven Transcription in Human Gastric Epithelial Cells. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063503
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063503
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر