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A Bio-Guided Fractionation to Assess the Inhibitory Activity of Calendula officinalis L. on the NF-κB Driven Transcription in Human Gastric Epithelial Cells
Joint Authors
D’Ambrosio, Michele
Bosisio, Enrica
Ciocarlan, Alexandru
Fumagalli, Marco
Guerriero, Antonio
Harghel, Petru
Dell'Agli, Mario
Colombo, Elisa
Sangiovanni, Enrico
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Calendula officinalis L.
has been largely known for its topical anti-inflammatory properties; however, there are no experimental evidences about its antiphlogistic effect at the gastric level.
To investigate whether marigold might exert an activity against gastric inflammation, a CH2Cl2 extract obtained from C.
officinalis flowers was evaluated in vitro on the NF-κB pathway.
The lipophilic extract demonstrated a significant inhibitory effect on the NF-κB driven transcription.
The identification of active compounds was conducted by a bio-guided fractionation of the extract that afforded 16 fractions.
Fraction J exhibited a concentration-dependent inhibitory activity on the NF-κB driven transcription and significantly contributed to the antiphlogistic effect showed by CH2Cl2 extract.
The main components of fraction J were loliolide and the fucoside acetates of β-eudesmol and viridiflorol.
HPLC analysis of fractions D and E led to the identification and isolation of triterpene esters that showed a concentration-dependent inhibition of the NF-κB driven transcription, with faradiol-3-myristate and the corresponding aglycone being the most active compounds.
The present study provides some experimental evidences that Calendula officinalis L.
may exert an anti-inflammatory activity on the gastric district by the inhibition of the NF-κB system, identifying the compounds responsible, at least in part, for the observed effect.
American Psychological Association (APA)
Colombo, Elisa& Sangiovanni, Enrico& D’Ambrosio, Michele& Bosisio, Enrica& Ciocarlan, Alexandru& Fumagalli, Marco…[et al.]. 2015. A Bio-Guided Fractionation to Assess the Inhibitory Activity of Calendula officinalis L. on the NF-κB Driven Transcription in Human Gastric Epithelial Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063503
Modern Language Association (MLA)
Colombo, Elisa…[et al.]. A Bio-Guided Fractionation to Assess the Inhibitory Activity of Calendula officinalis L. on the NF-κB Driven Transcription in Human Gastric Epithelial Cells. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063503
American Medical Association (AMA)
Colombo, Elisa& Sangiovanni, Enrico& D’Ambrosio, Michele& Bosisio, Enrica& Ciocarlan, Alexandru& Fumagalli, Marco…[et al.]. A Bio-Guided Fractionation to Assess the Inhibitory Activity of Calendula officinalis L. on the NF-κB Driven Transcription in Human Gastric Epithelial Cells. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063503