α-Mangostin Improves Glucose Uptake and Inhibits Adipocytes Differentiation in 3T3-L1 Cells via PPARγ, GLUT4, and Leptin Expressions
المؤلفون المشاركون
Susanti, D.
Zakaria, Zainul Amiruddin
Taher, Muhammad
Mohamed Amiroudine, Mohamed Zaffar Ali
Tengku Zakaria, Tengku Muhamad Faris Syafiq
Ichwan, Solachuddin J. A.
Kaderi, Mohd Arifin
Ahmed, Qamar Uddin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Obesity has been often associated with the occurrence of cardiovascular diseases, type 2 diabetes, and cancer.
The development of obesity is also accompanied by significant differentiation of preadipocytes into adipocytes.
In this study, we investigated the activity of α-mangostin, a major xanthone component isolated from the stem bark of G.
malaccensis, on glucose uptake and adipocyte differentiation of 3T3-L1 cells focusing on PPARγ, GLUT4, and leptin expressions.
α-Mangostin was found to inhibit cytoplasmic lipid accumulation and adipogenic differentiation.
Cells treated with 50 μM of α-mangostin reduced intracellular fat accumulation dose-dependently up to 44.4% relative to MDI-treated cells.
Analyses of 2-deoxy-D-[3H] glucose uptake activity showed that α-mangostin significantly improved the glucose uptake ( P < 0.05 ) with highest activity found at 25 μM.
In addition, α-mangostin increased the amount of free fatty acids (FFA) released.
The highest glycerol release level was observed at 50 μM of α-mangostin.
qRT-PCR analysis showed reduced lipid accumulation via inhibition of PPARγ gene expression.
Induction of glucose uptake and free fatty acid release by α-mangostin were accompanied by increasing mRNA expression of GLUT4 and leptin.
These evidences propose that α-mangostin might be possible candidate for the effective management of obesity in future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Taher, Muhammad& Mohamed Amiroudine, Mohamed Zaffar Ali& Tengku Zakaria, Tengku Muhamad Faris Syafiq& Susanti, D.& Ichwan, Solachuddin J. A.& Kaderi, Mohd Arifin…[et al.]. 2015. α-Mangostin Improves Glucose Uptake and Inhibits Adipocytes Differentiation in 3T3-L1 Cells via PPARγ, GLUT4, and Leptin Expressions. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063540
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Taher, Muhammad…[et al.]. α-Mangostin Improves Glucose Uptake and Inhibits Adipocytes Differentiation in 3T3-L1 Cells via PPARγ, GLUT4, and Leptin Expressions. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063540
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Taher, Muhammad& Mohamed Amiroudine, Mohamed Zaffar Ali& Tengku Zakaria, Tengku Muhamad Faris Syafiq& Susanti, D.& Ichwan, Solachuddin J. A.& Kaderi, Mohd Arifin…[et al.]. α-Mangostin Improves Glucose Uptake and Inhibits Adipocytes Differentiation in 3T3-L1 Cells via PPARγ, GLUT4, and Leptin Expressions. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063540
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063540
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر