Methanolic Extract of Ficus carica Linn. Leaves Exerts Antiangiogenesis Effects Based on the Rat Air Pouch Model of Inflammation
المؤلفون المشاركون
Delazar, Abbas
Eteraf-Oskouei, Tahereh
Allahyari, Saeideh
Akbarzadeh-Atashkhosrow, Arezu
Pashaii, Mahdiyeh
Najafi, Moslem
Gan, Siew Hua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The antiangiogenesis effect of Ficus carica leaves extract in an air pouch model of inflammation was investigated in rat.
Inflammation was induced by injection of carrageenan into pouches.
After antioxidant capacity and total phenolic content (TPC) investigations, the extract was administered at 5, 25, and 50 mg/pouch, and then the volume of exudates, the cell number, TNFα, PGE2, and VEGF levels were measured.
Angiogenesis of granulation tissues was determined by measuring hemoglobin content.
Based on the DPPH assay, the extract had significant antioxidant activity with TPC of 11.70 mg GAE/100 g dry sample.
In addition, leukocyte accumulation and volume of exudate were significantly inhibited by the extract.
Moreover, it significantly decreased the production of TNFα, PGE2, and VEGF, while angiogenesis was significantly inhibited by all administered doses.
Interestingly, attenuation of angiogenesis and inflammatory parameters (except leukocyte accumulation) by the extract was similar to that shown by diclofenac.
The extract has anti-inflammatory effects and ameliorated cell influx and exudation to the site of the inflammatory response which may be related to the local inhibition of TNFα, PGE2, and VEGF levels as similarly shown by diclofenac.
The antiangiogenesis and anti-VEGF effects of Ficus carica may be correlated with its significant antioxidant potentials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Eteraf-Oskouei, Tahereh& Allahyari, Saeideh& Akbarzadeh-Atashkhosrow, Arezu& Delazar, Abbas& Pashaii, Mahdiyeh& Gan, Siew Hua…[et al.]. 2015. Methanolic Extract of Ficus carica Linn. Leaves Exerts Antiangiogenesis Effects Based on the Rat Air Pouch Model of Inflammation. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063569
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Eteraf-Oskouei, Tahereh…[et al.]. Methanolic Extract of Ficus carica Linn. Leaves Exerts Antiangiogenesis Effects Based on the Rat Air Pouch Model of Inflammation. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063569
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Eteraf-Oskouei, Tahereh& Allahyari, Saeideh& Akbarzadeh-Atashkhosrow, Arezu& Delazar, Abbas& Pashaii, Mahdiyeh& Gan, Siew Hua…[et al.]. Methanolic Extract of Ficus carica Linn. Leaves Exerts Antiangiogenesis Effects Based on the Rat Air Pouch Model of Inflammation. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063569
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063569
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر