Methanolic Extract of Ficus carica Linn. Leaves Exerts Antiangiogenesis Effects Based on the Rat Air Pouch Model of Inflammation
Joint Authors
Delazar, Abbas
Eteraf-Oskouei, Tahereh
Allahyari, Saeideh
Akbarzadeh-Atashkhosrow, Arezu
Pashaii, Mahdiyeh
Najafi, Moslem
Gan, Siew Hua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The antiangiogenesis effect of Ficus carica leaves extract in an air pouch model of inflammation was investigated in rat.
Inflammation was induced by injection of carrageenan into pouches.
After antioxidant capacity and total phenolic content (TPC) investigations, the extract was administered at 5, 25, and 50 mg/pouch, and then the volume of exudates, the cell number, TNFα, PGE2, and VEGF levels were measured.
Angiogenesis of granulation tissues was determined by measuring hemoglobin content.
Based on the DPPH assay, the extract had significant antioxidant activity with TPC of 11.70 mg GAE/100 g dry sample.
In addition, leukocyte accumulation and volume of exudate were significantly inhibited by the extract.
Moreover, it significantly decreased the production of TNFα, PGE2, and VEGF, while angiogenesis was significantly inhibited by all administered doses.
Interestingly, attenuation of angiogenesis and inflammatory parameters (except leukocyte accumulation) by the extract was similar to that shown by diclofenac.
The extract has anti-inflammatory effects and ameliorated cell influx and exudation to the site of the inflammatory response which may be related to the local inhibition of TNFα, PGE2, and VEGF levels as similarly shown by diclofenac.
The antiangiogenesis and anti-VEGF effects of Ficus carica may be correlated with its significant antioxidant potentials.
American Psychological Association (APA)
Eteraf-Oskouei, Tahereh& Allahyari, Saeideh& Akbarzadeh-Atashkhosrow, Arezu& Delazar, Abbas& Pashaii, Mahdiyeh& Gan, Siew Hua…[et al.]. 2015. Methanolic Extract of Ficus carica Linn. Leaves Exerts Antiangiogenesis Effects Based on the Rat Air Pouch Model of Inflammation. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063569
Modern Language Association (MLA)
Eteraf-Oskouei, Tahereh…[et al.]. Methanolic Extract of Ficus carica Linn. Leaves Exerts Antiangiogenesis Effects Based on the Rat Air Pouch Model of Inflammation. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063569
American Medical Association (AMA)
Eteraf-Oskouei, Tahereh& Allahyari, Saeideh& Akbarzadeh-Atashkhosrow, Arezu& Delazar, Abbas& Pashaii, Mahdiyeh& Gan, Siew Hua…[et al.]. Methanolic Extract of Ficus carica Linn. Leaves Exerts Antiangiogenesis Effects Based on the Rat Air Pouch Model of Inflammation. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063569
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063569