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The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice
المؤلفون المشاركون
Chen, Lijuan
Yan, Xin
Yan, Qianlin
Fan, Jiajun
Huang, Hai
Shi, Xunlong
Han, Lei
Han, Tianxiong
Zhu, Haiyan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
A new approach to treat infections of highly pathogenic influenza virus is to inhibit excessive innate immune response.
JiuWei QiangHuo decoction has been used for centuries for the treatment of pulmonary disorders in China.
In this study, we evaluated the anti-inflammatory activities of the modified JiuWei QiangHuo (MJWQH) decoction in the treatment of influenza A (H1N1) virus-induced severe pneumonia in mice.
The results showed that MJWQH significantly increased the survival rate of H1N1-infected mice and suppressed the production of TNF-α, IL-1, IL-6, MCP-1, RANTES, and IFN-α on day 4 after infection.
Moreover, oral administration of MJWQH efficiently inhibited virus replication and alleviated the severity of lung injuries.
The results also showed that MJWQH may have potential therapeutic effect on severe lung injury induced by H1N1 virus by regulating the NF-κB pathway.
Our study suggested that MJWQH might be an alternative therapy for the treatment of viral pneumonia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Lijuan& Yan, Xin& Yan, Qianlin& Fan, Jiajun& Huang, Hai& Shi, Xunlong…[et al.]. 2015. The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063595
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Lijuan…[et al.]. The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1063595
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Lijuan& Yan, Xin& Yan, Qianlin& Fan, Jiajun& Huang, Hai& Shi, Xunlong…[et al.]. The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063595
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063595
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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