The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice
Joint Authors
Chen, Lijuan
Yan, Xin
Yan, Qianlin
Fan, Jiajun
Huang, Hai
Shi, Xunlong
Han, Lei
Han, Tianxiong
Zhu, Haiyan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
A new approach to treat infections of highly pathogenic influenza virus is to inhibit excessive innate immune response.
JiuWei QiangHuo decoction has been used for centuries for the treatment of pulmonary disorders in China.
In this study, we evaluated the anti-inflammatory activities of the modified JiuWei QiangHuo (MJWQH) decoction in the treatment of influenza A (H1N1) virus-induced severe pneumonia in mice.
The results showed that MJWQH significantly increased the survival rate of H1N1-infected mice and suppressed the production of TNF-α, IL-1, IL-6, MCP-1, RANTES, and IFN-α on day 4 after infection.
Moreover, oral administration of MJWQH efficiently inhibited virus replication and alleviated the severity of lung injuries.
The results also showed that MJWQH may have potential therapeutic effect on severe lung injury induced by H1N1 virus by regulating the NF-κB pathway.
Our study suggested that MJWQH might be an alternative therapy for the treatment of viral pneumonia.
American Psychological Association (APA)
Chen, Lijuan& Yan, Xin& Yan, Qianlin& Fan, Jiajun& Huang, Hai& Shi, Xunlong…[et al.]. 2015. The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063595
Modern Language Association (MLA)
Chen, Lijuan…[et al.]. The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1063595
American Medical Association (AMA)
Chen, Lijuan& Yan, Xin& Yan, Qianlin& Fan, Jiajun& Huang, Hai& Shi, Xunlong…[et al.]. The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063595
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063595
