Adenosine A2A Receptors Mediate Anti-Inflammatory Effects of Electroacupuncture on Synovitis in Mice with Collagen-Induced Arthritis
المؤلفون المشاركون
Li, Qi-hui
Xie, Wen-xia
Li, Xiao-pei
Huang, Ka-te
Du, Zhong-heng
Cong, Wen-jie
Zhou, Long-hua
Ye, Tian-shen
Chen, Jiang-Fan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-16
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
To study the role of adenosine A2A receptor (A2AR) in mediating the anti-inflammatory effect of electroacupuncture (EA) on synovitis in collagen-induced arthritis (CIA), C57BL/6 mice were divided into five treatment groups: Sham-control, CIA-control, CIA-EA, CIA-SCH58261 (A2AR antagonist), and CIA-EA-SCH58261.
All mice except those in the Sham-control group were immunized with collagen II for arthritis induction.
EA treatment was administered using the stomach 36 and spleen 6 points, and stimulated with a continuous rectangular wave for 30 min daily.
EA treatment and SCH58261 were administered daily from days 35 to 49 (n=10).
After treatment, X-ray radiography of joint bone morphology was established at day 60 and mouse blood was collected for ELISA determination of tumor necrosis factor alpha (TNF-α) levels.
Mice were sacrificed and processed for histological examination of pathological changes of joint tissue, including hematoxylin-eosin staining and immunohistochemistry of A2AR expression.
EA treatment resulted in significantly reduced pathological scores, TNF-α concentrations, and bone damage X-ray scores.
Importantly, the anti-inflammatory and tissue-protective effect of EA treatment was reversed by coadministration of SCH58261.
Thus, EA treatment exerts an anti-inflammatory effect resulting in significant protection of cartilage by activation of A2AR in the synovial tissue of CIA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Qi-hui& Xie, Wen-xia& Li, Xiao-pei& Huang, Ka-te& Du, Zhong-heng& Cong, Wen-jie…[et al.]. 2015. Adenosine A2A Receptors Mediate Anti-Inflammatory Effects of Electroacupuncture on Synovitis in Mice with Collagen-Induced Arthritis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063618
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Qi-hui…[et al.]. Adenosine A2A Receptors Mediate Anti-Inflammatory Effects of Electroacupuncture on Synovitis in Mice with Collagen-Induced Arthritis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1063618
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Qi-hui& Xie, Wen-xia& Li, Xiao-pei& Huang, Ka-te& Du, Zhong-heng& Cong, Wen-jie…[et al.]. Adenosine A2A Receptors Mediate Anti-Inflammatory Effects of Electroacupuncture on Synovitis in Mice with Collagen-Induced Arthritis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063618
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063618
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر