Neuroprotective Activity of Coptisine from Coptis chinensis (Franch)
المؤلفون المشاركون
Schumacher, Udo
Tao, Yi
Leung, Alexander Kai-Man
Friedemann, Thomas
Schroeder, Sven
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Coptis chinensis rhizomes (CR) are one important ingredient of traditional Chinese herbal formulas such as San-Huang-Xie-Xin-Tang which is used for treatment of cardiovascular and neurodegenerative diseases.
Recent studies suggest that the extract of CR might be a potential therapeutic agent for amelioration of neurological disorders associated with oxidative stress.
In the present study we aimed at revealing the main active compound(s) of the CR extract and at investigating the mechanism of action.
Four main alkaloids of the CR extract (berberine, coptisine, jatrorrhizine, and palmatine) were selected for this study.
Results showed that out of those alkaloids only pretreatment with coptisine significantly attenuated tert-butylhydroperoxide induced reduction of cell viability, increased rate of apoptosis, and declined mitochondrial membrane potential.
Elisa assay and quantitative real-time PCR analyses revealed that thioredoxin-interacting protein (TXNIP) gene expression was downregulated by coptisine, which could explain the neuroprotective effect, hypothetically, by strengthening the thioredoxin defense system against oxidative stress and attenuation of apoptosis signal-regulating kinase (Ask1) mediated apoptotic signaling.
A comparison between coptisine and CR extract identified coptisine as the main single component responsible for the neuroprotective effect.
Based on the results the CR extract and coptisine are promising candidate agents for prevention or improvement of diabetic neuropathy and neurodegenerative disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Friedemann, Thomas& Schumacher, Udo& Tao, Yi& Leung, Alexander Kai-Man& Schroeder, Sven. 2015. Neuroprotective Activity of Coptisine from Coptis chinensis (Franch). Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063656
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Friedemann, Thomas…[et al.]. Neuroprotective Activity of Coptisine from Coptis chinensis (Franch). Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063656
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Friedemann, Thomas& Schumacher, Udo& Tao, Yi& Leung, Alexander Kai-Man& Schroeder, Sven. Neuroprotective Activity of Coptisine from Coptis chinensis (Franch). Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063656
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063656
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر