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Neuroprotective Activity of Coptisine from Coptis chinensis (Franch)
Joint Authors
Schumacher, Udo
Tao, Yi
Leung, Alexander Kai-Man
Friedemann, Thomas
Schroeder, Sven
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Coptis chinensis rhizomes (CR) are one important ingredient of traditional Chinese herbal formulas such as San-Huang-Xie-Xin-Tang which is used for treatment of cardiovascular and neurodegenerative diseases.
Recent studies suggest that the extract of CR might be a potential therapeutic agent for amelioration of neurological disorders associated with oxidative stress.
In the present study we aimed at revealing the main active compound(s) of the CR extract and at investigating the mechanism of action.
Four main alkaloids of the CR extract (berberine, coptisine, jatrorrhizine, and palmatine) were selected for this study.
Results showed that out of those alkaloids only pretreatment with coptisine significantly attenuated tert-butylhydroperoxide induced reduction of cell viability, increased rate of apoptosis, and declined mitochondrial membrane potential.
Elisa assay and quantitative real-time PCR analyses revealed that thioredoxin-interacting protein (TXNIP) gene expression was downregulated by coptisine, which could explain the neuroprotective effect, hypothetically, by strengthening the thioredoxin defense system against oxidative stress and attenuation of apoptosis signal-regulating kinase (Ask1) mediated apoptotic signaling.
A comparison between coptisine and CR extract identified coptisine as the main single component responsible for the neuroprotective effect.
Based on the results the CR extract and coptisine are promising candidate agents for prevention or improvement of diabetic neuropathy and neurodegenerative disorders.
American Psychological Association (APA)
Friedemann, Thomas& Schumacher, Udo& Tao, Yi& Leung, Alexander Kai-Man& Schroeder, Sven. 2015. Neuroprotective Activity of Coptisine from Coptis chinensis (Franch). Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063656
Modern Language Association (MLA)
Friedemann, Thomas…[et al.]. Neuroprotective Activity of Coptisine from Coptis chinensis (Franch). Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063656
American Medical Association (AMA)
Friedemann, Thomas& Schumacher, Udo& Tao, Yi& Leung, Alexander Kai-Man& Schroeder, Sven. Neuroprotective Activity of Coptisine from Coptis chinensis (Franch). Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063656