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Traditional Korean Herbal Formula Samsoeum Attenuates Adipogenesis by Regulating the Phosphorylation of ERK12 in 3T3-L1 Cells
المؤلفون المشاركون
Shin, Hyeun-Kyoo
Seo, Chang-Seob
Yoo, Sae-Rom
Jeong, Soo-Jin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Adipogenesis is the cell differentiation process from preadipocytes into adipocytes and the critical action in the development of obesity.
In the present study, we conducted in vitro analyses to investigate the inhibitory effects of Samsoeum (SSE), a traditional herbal decoction.
SSE had no significant cytotoxic effect against either the undifferentiated or differentiated 3T3-L1 cells.
Oil Red O staining results showed that SSE significantly inhibited fat accumulation in adipocytes.
SSE treatment consistently reduced the intracellular triglyceride content in the cells.
SSE significantly inactivated glycerol-3-phosphate dehydrogenase (GPDH), a major link between carbohydrate and lipid metabolisms in 3T3-L1 adipocytes, and markedly inhibited the production of leptin, an important adipokine, in differentiated cells.
SSE markedly suppressed the mRNA expression of the adipogenesis-related genes peroxisome proliferator-activated receptor-gamma (PPAR-γ), CCAAT/enhancer binding protein-alpha (C/EBP-α), fatty acid synthase (FAS), lipoprotein lipase (LPL), and fatty acid binding protein 4 (FABP4).
Importantly, SSE increased the phosphorylation of ERK1/2, but not p38 MAPK and JNK, in adipose cells.
Overall, our results indicate that SSE exerts antiadipogenic activity and modulates expressions of adipogenesis-related genes and ERK1/2 activation in adipocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jeong, Soo-Jin& Yoo, Sae-Rom& Seo, Chang-Seob& Shin, Hyeun-Kyoo. 2015. Traditional Korean Herbal Formula Samsoeum Attenuates Adipogenesis by Regulating the Phosphorylation of ERK12 in 3T3-L1 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063726
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jeong, Soo-Jin…[et al.]. Traditional Korean Herbal Formula Samsoeum Attenuates Adipogenesis by Regulating the Phosphorylation of ERK12 in 3T3-L1 Cells. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1063726
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jeong, Soo-Jin& Yoo, Sae-Rom& Seo, Chang-Seob& Shin, Hyeun-Kyoo. Traditional Korean Herbal Formula Samsoeum Attenuates Adipogenesis by Regulating the Phosphorylation of ERK12 in 3T3-L1 Cells. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063726
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063726
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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