Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism
المؤلفون المشاركون
Zazueta, Cecilia
García-Niño, Wylly Ramsés
León-Contreras, Juan Carlos
Aparicio-Trejo, Omar Emiliano
Madero, Magdalena
Negrette-Guzmán, Mario
Tapia, Edilia
Hernández-Pando, Rogelio
Pedraza-Chaverri, José
Huerta-Yepez, Sara
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-05
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
It has been shown that curcumin (CUR), a polyphenol derived from Curcuma longa, exerts a protective effect against gentamicin- (GM-) induced nephrotoxicity in rats, associated with a preservation of the antioxidant status.
Although mitochondrial dysfunction is a hallmark in the GM-induced renal injury, the role of CUR in mitochondrial protection has not been studied.
In this work, LLC-PK1 cells were preincubated 24 h with CUR and then coincubated 48 h with CUR and 8 mM GM.
Treatment with CUR attenuated GM-induced drop in cell viability and led to an increase in nuclear factor (erythroid-2)-related factor 2 (Nrf2) nuclear accumulation and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) cell expression attenuating GM-induced losses in these proteins.
In vivo, Wistar rats were injected subcutaneously with GM (75 mg/Kg/12 h) during 7 days to develop kidney mitochondrial alterations.
CUR (400 mg/Kg/day) was administered orally 5 days before and during the GM exposure.
The GM-induced mitochondrial alterations in ultrastructure and bioenergetics as well as decrease in activities of respiratory complexes I and IV and induction of calcium-dependent permeability transition were mostly attenuated by CUR.
Protection of CUR against GM-induced nephrotoxicity could be in part mediated by maintenance of mitochondrial functions and biogenesis with some participation of the nuclear factor Nrf2.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Negrette-Guzmán, Mario& García-Niño, Wylly Ramsés& Tapia, Edilia& Zazueta, Cecilia& Huerta-Yepez, Sara& León-Contreras, Juan Carlos…[et al.]. 2015. Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1063795
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Negrette-Guzmán, Mario…[et al.]. Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1063795
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Negrette-Guzmán, Mario& García-Niño, Wylly Ramsés& Tapia, Edilia& Zazueta, Cecilia& Huerta-Yepez, Sara& León-Contreras, Juan Carlos…[et al.]. Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1063795
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063795
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر