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Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism
Joint Authors
Zazueta, Cecilia
García-Niño, Wylly Ramsés
León-Contreras, Juan Carlos
Aparicio-Trejo, Omar Emiliano
Madero, Magdalena
Negrette-Guzmán, Mario
Tapia, Edilia
Hernández-Pando, Rogelio
Pedraza-Chaverri, José
Huerta-Yepez, Sara
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-05
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
It has been shown that curcumin (CUR), a polyphenol derived from Curcuma longa, exerts a protective effect against gentamicin- (GM-) induced nephrotoxicity in rats, associated with a preservation of the antioxidant status.
Although mitochondrial dysfunction is a hallmark in the GM-induced renal injury, the role of CUR in mitochondrial protection has not been studied.
In this work, LLC-PK1 cells were preincubated 24 h with CUR and then coincubated 48 h with CUR and 8 mM GM.
Treatment with CUR attenuated GM-induced drop in cell viability and led to an increase in nuclear factor (erythroid-2)-related factor 2 (Nrf2) nuclear accumulation and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) cell expression attenuating GM-induced losses in these proteins.
In vivo, Wistar rats were injected subcutaneously with GM (75 mg/Kg/12 h) during 7 days to develop kidney mitochondrial alterations.
CUR (400 mg/Kg/day) was administered orally 5 days before and during the GM exposure.
The GM-induced mitochondrial alterations in ultrastructure and bioenergetics as well as decrease in activities of respiratory complexes I and IV and induction of calcium-dependent permeability transition were mostly attenuated by CUR.
Protection of CUR against GM-induced nephrotoxicity could be in part mediated by maintenance of mitochondrial functions and biogenesis with some participation of the nuclear factor Nrf2.
American Psychological Association (APA)
Negrette-Guzmán, Mario& García-Niño, Wylly Ramsés& Tapia, Edilia& Zazueta, Cecilia& Huerta-Yepez, Sara& León-Contreras, Juan Carlos…[et al.]. 2015. Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1063795
Modern Language Association (MLA)
Negrette-Guzmán, Mario…[et al.]. Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1063795
American Medical Association (AMA)
Negrette-Guzmán, Mario& García-Niño, Wylly Ramsés& Tapia, Edilia& Zazueta, Cecilia& Huerta-Yepez, Sara& León-Contreras, Juan Carlos…[et al.]. Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1063795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063795