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Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis through STAT3 Signal Pathway in Glioma Cell
المؤلفون المشاركون
Ding, Hong
Shen, Jinglian
Yang, Yang
Che, Yuqin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-15
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Signal transducer and activator of transcription factor 3 (STAT3) plays an important role in the proliferation and angiogenesis in human glioma.
Previous research indicated that saw palmetto extract markedly inhibited the proliferation of human glioma cells through STAT3 signal pathway.
But its effect on tumor metastasis and antiangiogenesis is not clear.
This study is to further clear the impact of saw palmetto extract on glioma cell metastasis, antiangiogenesis, and its mechanism.
TUNEL assay indicated that the apoptotic cells in the saw palmetto treated group are higher than that in the control group (p<0.05).
The apoptosis related protein is detected and the results revealed that saw palmetto extract inhibits the proliferation of human glioma.
Meanwhile pSTAT3 is lower in the experimental group and CD34 is also inhibited in the saw palmetto treated group.
This means that saw palmetto extract could inhibit the angiogenesis in glioma.
We found that saw palmetto extract was an important phytotherapeutic drug against the human glioma through STAT3 signal pathway.
Saw palmetto extract may be useful as an adjunctive therapeutic agent for treatment of individuals with glioma and other types of cancer in which STAT3 signaling is activated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ding, Hong& Shen, Jinglian& Yang, Yang& Che, Yuqin. 2015. Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis through STAT3 Signal Pathway in Glioma Cell. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063811
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ding, Hong…[et al.]. Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis through STAT3 Signal Pathway in Glioma Cell. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063811
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ding, Hong& Shen, Jinglian& Yang, Yang& Che, Yuqin. Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis through STAT3 Signal Pathway in Glioma Cell. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063811
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063811
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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