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Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis through STAT3 Signal Pathway in Glioma Cell
Joint Authors
Ding, Hong
Shen, Jinglian
Yang, Yang
Che, Yuqin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Signal transducer and activator of transcription factor 3 (STAT3) plays an important role in the proliferation and angiogenesis in human glioma.
Previous research indicated that saw palmetto extract markedly inhibited the proliferation of human glioma cells through STAT3 signal pathway.
But its effect on tumor metastasis and antiangiogenesis is not clear.
This study is to further clear the impact of saw palmetto extract on glioma cell metastasis, antiangiogenesis, and its mechanism.
TUNEL assay indicated that the apoptotic cells in the saw palmetto treated group are higher than that in the control group (p<0.05).
The apoptosis related protein is detected and the results revealed that saw palmetto extract inhibits the proliferation of human glioma.
Meanwhile pSTAT3 is lower in the experimental group and CD34 is also inhibited in the saw palmetto treated group.
This means that saw palmetto extract could inhibit the angiogenesis in glioma.
We found that saw palmetto extract was an important phytotherapeutic drug against the human glioma through STAT3 signal pathway.
Saw palmetto extract may be useful as an adjunctive therapeutic agent for treatment of individuals with glioma and other types of cancer in which STAT3 signaling is activated.
American Psychological Association (APA)
Ding, Hong& Shen, Jinglian& Yang, Yang& Che, Yuqin. 2015. Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis through STAT3 Signal Pathway in Glioma Cell. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063811
Modern Language Association (MLA)
Ding, Hong…[et al.]. Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis through STAT3 Signal Pathway in Glioma Cell. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063811
American Medical Association (AMA)
Ding, Hong& Shen, Jinglian& Yang, Yang& Che, Yuqin. Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis through STAT3 Signal Pathway in Glioma Cell. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063811