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Kainic Acid-Induced Excitotoxicity Experimental Model: Protective Merits of Natural Products and Plant Extracts
المؤلفون المشاركون
Sulaiman, Siti Amrah
Swamy, M.
Mohd Sairazi, Nur Shafika
Asari, Mohd Asnizam
Muzaimi, Mustapha
Sirajudeen, Kuttulebbai N. S.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-17
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Excitotoxicity is well recognized as a major pathological process of neuronal death in neurodegenerative diseases involving the central nervous system (CNS).
In the animal models of neurodegeneration, excitotoxicity is commonly induced experimentally by chemical convulsants, particularly kainic acid (KA).
KA-induced excitotoxicity in rodent models has been shown to result in seizures, behavioral changes, oxidative stress, glial activation, inflammatory mediator production, endoplasmic reticulum stress, mitochondrial dysfunction, and selective neurodegeneration in the brain upon KA administration.
Recently, there is an emerging trend to search for natural sources to combat against excitotoxicity-associated neurodegenerative diseases.
Natural products and plant extracts had attracted a considerable amount of attention because of their reported beneficial effects on the CNS, particularly their neuroprotective effect against excitotoxicity.
They provide significant reduction and/or protection against the development and progression of acute and chronic neurodegeneration.
This indicates that natural products and plants extracts may be useful in protecting against excitotoxicity-associated neurodegeneration.
Thus, targeting of multiple pathways simultaneously may be the strategy to maximize the neuroprotection effect.
This review summarizes the mechanisms involved in KA-induced excitotoxicity and attempts to collate the various researches related to the protective effect of natural products and plant extracts in the KA model of neurodegeneration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mohd Sairazi, Nur Shafika& Sirajudeen, Kuttulebbai N. S.& Asari, Mohd Asnizam& Muzaimi, Mustapha& Swamy, M.& Sulaiman, Siti Amrah. 2015. Kainic Acid-Induced Excitotoxicity Experimental Model: Protective Merits of Natural Products and Plant Extracts. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1063852
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mohd Sairazi, Nur Shafika…[et al.]. Kainic Acid-Induced Excitotoxicity Experimental Model: Protective Merits of Natural Products and Plant Extracts. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1063852
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mohd Sairazi, Nur Shafika& Sirajudeen, Kuttulebbai N. S.& Asari, Mohd Asnizam& Muzaimi, Mustapha& Swamy, M.& Sulaiman, Siti Amrah. Kainic Acid-Induced Excitotoxicity Experimental Model: Protective Merits of Natural Products and Plant Extracts. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1063852
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063852
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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