Kainic Acid-Induced Excitotoxicity Experimental Model: Protective Merits of Natural Products and Plant Extracts
Joint Authors
Sulaiman, Siti Amrah
Swamy, M.
Mohd Sairazi, Nur Shafika
Asari, Mohd Asnizam
Muzaimi, Mustapha
Sirajudeen, Kuttulebbai N. S.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-17
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Excitotoxicity is well recognized as a major pathological process of neuronal death in neurodegenerative diseases involving the central nervous system (CNS).
In the animal models of neurodegeneration, excitotoxicity is commonly induced experimentally by chemical convulsants, particularly kainic acid (KA).
KA-induced excitotoxicity in rodent models has been shown to result in seizures, behavioral changes, oxidative stress, glial activation, inflammatory mediator production, endoplasmic reticulum stress, mitochondrial dysfunction, and selective neurodegeneration in the brain upon KA administration.
Recently, there is an emerging trend to search for natural sources to combat against excitotoxicity-associated neurodegenerative diseases.
Natural products and plant extracts had attracted a considerable amount of attention because of their reported beneficial effects on the CNS, particularly their neuroprotective effect against excitotoxicity.
They provide significant reduction and/or protection against the development and progression of acute and chronic neurodegeneration.
This indicates that natural products and plants extracts may be useful in protecting against excitotoxicity-associated neurodegeneration.
Thus, targeting of multiple pathways simultaneously may be the strategy to maximize the neuroprotection effect.
This review summarizes the mechanisms involved in KA-induced excitotoxicity and attempts to collate the various researches related to the protective effect of natural products and plant extracts in the KA model of neurodegeneration.
American Psychological Association (APA)
Mohd Sairazi, Nur Shafika& Sirajudeen, Kuttulebbai N. S.& Asari, Mohd Asnizam& Muzaimi, Mustapha& Swamy, M.& Sulaiman, Siti Amrah. 2015. Kainic Acid-Induced Excitotoxicity Experimental Model: Protective Merits of Natural Products and Plant Extracts. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1063852
Modern Language Association (MLA)
Mohd Sairazi, Nur Shafika…[et al.]. Kainic Acid-Induced Excitotoxicity Experimental Model: Protective Merits of Natural Products and Plant Extracts. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1063852
American Medical Association (AMA)
Mohd Sairazi, Nur Shafika& Sirajudeen, Kuttulebbai N. S.& Asari, Mohd Asnizam& Muzaimi, Mustapha& Swamy, M.& Sulaiman, Siti Amrah. Kainic Acid-Induced Excitotoxicity Experimental Model: Protective Merits of Natural Products and Plant Extracts. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1063852
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063852