Systems Pharmacology Dissecting Holistic Medicine for Treatment of Complex Diseases: An Example Using Cardiocerebrovascular Diseases Treated by TCM
المؤلفون المشاركون
Zhang, Boli
Zheng, Chunli
Huang, Chao
Chen, Xuetong
Wu, Ziyin
Wang, Zhenzhong
Xiao, Wei
Li, Yan
Wang, Yonghua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-26
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Holistic medicine is an interdisciplinary field of study that integrates all types of biological information (protein, small molecules, tissues, organs, external environmental signals, etc.) to lead to predictive and actionable models for health care and disease treatment.
Despite the global and integrative character of this discipline, a comprehensive picture of holistic medicine for the treatment of complex diseases is still lacking.
In this study, we develop a novel systems pharmacology approach to dissect holistic medicine in treating cardiocerebrovascular diseases (CCDs) by TCM (traditional Chinese medicine).
Firstly, by applying the TCM active ingredients screened out by a systems-ADME process, we explored and experimentalized the signed drug-target interactions for revealing the pharmacological actions of drugs at a molecule level.
Then, at a/an tissue/organ level, the drug therapeutic mechanisms were further investigated by a target-organ location method.
Finally, a translational integrating pathway approach was applied to extract the diseases-therapeutic modules for understanding the complex disease and its therapy at systems level.
For the first time, the feature of the drug-target-pathway-organ-cooperations for treatment of multiple organ diseases in holistic medicine was revealed, facilitating the development of novel treatment paradigm for complex diseases in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yonghua& Zheng, Chunli& Huang, Chao& Li, Yan& Chen, Xuetong& Wu, Ziyin…[et al.]. 2015. Systems Pharmacology Dissecting Holistic Medicine for Treatment of Complex Diseases: An Example Using Cardiocerebrovascular Diseases Treated by TCM. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1063862
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yonghua…[et al.]. Systems Pharmacology Dissecting Holistic Medicine for Treatment of Complex Diseases: An Example Using Cardiocerebrovascular Diseases Treated by TCM. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-19.
https://search.emarefa.net/detail/BIM-1063862
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yonghua& Zheng, Chunli& Huang, Chao& Li, Yan& Chen, Xuetong& Wu, Ziyin…[et al.]. Systems Pharmacology Dissecting Holistic Medicine for Treatment of Complex Diseases: An Example Using Cardiocerebrovascular Diseases Treated by TCM. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1063862
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063862
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر