Systems Pharmacology Dissecting Holistic Medicine for Treatment of Complex Diseases: An Example Using Cardiocerebrovascular Diseases Treated by TCM
Joint Authors
Zhang, Boli
Zheng, Chunli
Huang, Chao
Chen, Xuetong
Wu, Ziyin
Wang, Zhenzhong
Xiao, Wei
Li, Yan
Wang, Yonghua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-26
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Holistic medicine is an interdisciplinary field of study that integrates all types of biological information (protein, small molecules, tissues, organs, external environmental signals, etc.) to lead to predictive and actionable models for health care and disease treatment.
Despite the global and integrative character of this discipline, a comprehensive picture of holistic medicine for the treatment of complex diseases is still lacking.
In this study, we develop a novel systems pharmacology approach to dissect holistic medicine in treating cardiocerebrovascular diseases (CCDs) by TCM (traditional Chinese medicine).
Firstly, by applying the TCM active ingredients screened out by a systems-ADME process, we explored and experimentalized the signed drug-target interactions for revealing the pharmacological actions of drugs at a molecule level.
Then, at a/an tissue/organ level, the drug therapeutic mechanisms were further investigated by a target-organ location method.
Finally, a translational integrating pathway approach was applied to extract the diseases-therapeutic modules for understanding the complex disease and its therapy at systems level.
For the first time, the feature of the drug-target-pathway-organ-cooperations for treatment of multiple organ diseases in holistic medicine was revealed, facilitating the development of novel treatment paradigm for complex diseases in the future.
American Psychological Association (APA)
Wang, Yonghua& Zheng, Chunli& Huang, Chao& Li, Yan& Chen, Xuetong& Wu, Ziyin…[et al.]. 2015. Systems Pharmacology Dissecting Holistic Medicine for Treatment of Complex Diseases: An Example Using Cardiocerebrovascular Diseases Treated by TCM. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1063862
Modern Language Association (MLA)
Wang, Yonghua…[et al.]. Systems Pharmacology Dissecting Holistic Medicine for Treatment of Complex Diseases: An Example Using Cardiocerebrovascular Diseases Treated by TCM. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-19.
https://search.emarefa.net/detail/BIM-1063862
American Medical Association (AMA)
Wang, Yonghua& Zheng, Chunli& Huang, Chao& Li, Yan& Chen, Xuetong& Wu, Ziyin…[et al.]. Systems Pharmacology Dissecting Holistic Medicine for Treatment of Complex Diseases: An Example Using Cardiocerebrovascular Diseases Treated by TCM. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1063862
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063862