Eucommia ulmoides Oliv. (Du-Zhong) Lignans Inhibit Angiotensin II-Stimulated Proliferation by Affecting P21, P27, and Bax Expression in Rat Mesangial Cells
المؤلفون المشاركون
Zhou, Hong-Hao
Chen, Yao
Jing, Xian
Huang, Wei-Hua
Tang, Yong-Jun
Wang, Ya-Qin
Li, Hui
Tian, Ying-Ying
Ou-Yang, Dong-Sheng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-10
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Cortex Eucommiae (Du-zhong) is the dried bark of the Eucommia ulmoides Oliv.
The natural products identified from Du-zhong include lignans, iridoids, flavonoids, polysaccharides, terpenes, and proteins, Liu et al.
(2012).
Lignans, the main bioactive components, were protective against hypertensive renal injury in spontaneous hypertensive rats in our previous study, Li et al.
(2012).
Moreover, Eucommia lignans also diminished aldose reductase (AR) overexpression in the kidney, Li et al.
(2012).
However, the pathological mechanism underlying the protective effects of Eucommia lignans remains unknown.
Cellular proliferation was reported to contribute to important pathological changes in hypertensive renal injuries, and increased angiotensin II (Ang II) expression was reported to be essential for target-organ damage during hypertension.
Ang II is the main effective peptide in the renin-angiotensin system and is considered to be a key mediator in the development of hypertensive nephropathy, Rüster and Wolf (2011).
Our preliminary results showed that Eucommia lignans had inhibitory effects on Ang II-induced proliferation of rat mesangial cells.
In the present study, we investigated the effects of Eucommia ulmoides on Ang II-induced proliferation and apoptosis of rat mesangial cells.
Cell cycle-related genes P21 and P27, and cell apoptosis-related genes Bax and Bcl-2, were determined.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jing, Xian& Huang, Wei-Hua& Tang, Yong-Jun& Wang, Ya-Qin& Li, Hui& Tian, Ying-Ying…[et al.]. 2015. Eucommia ulmoides Oliv. (Du-Zhong) Lignans Inhibit Angiotensin II-Stimulated Proliferation by Affecting P21, P27, and Bax Expression in Rat Mesangial Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063871
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jing, Xian…[et al.]. Eucommia ulmoides Oliv. (Du-Zhong) Lignans Inhibit Angiotensin II-Stimulated Proliferation by Affecting P21, P27, and Bax Expression in Rat Mesangial Cells. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063871
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jing, Xian& Huang, Wei-Hua& Tang, Yong-Jun& Wang, Ya-Qin& Li, Hui& Tian, Ying-Ying…[et al.]. Eucommia ulmoides Oliv. (Du-Zhong) Lignans Inhibit Angiotensin II-Stimulated Proliferation by Affecting P21, P27, and Bax Expression in Rat Mesangial Cells. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063871
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063871
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر