Eucommia ulmoides Oliv. (Du-Zhong) Lignans Inhibit Angiotensin II-Stimulated Proliferation by Affecting P21, P27, and Bax Expression in Rat Mesangial Cells
Joint Authors
Zhou, Hong-Hao
Chen, Yao
Jing, Xian
Huang, Wei-Hua
Tang, Yong-Jun
Wang, Ya-Qin
Li, Hui
Tian, Ying-Ying
Ou-Yang, Dong-Sheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cortex Eucommiae (Du-zhong) is the dried bark of the Eucommia ulmoides Oliv.
The natural products identified from Du-zhong include lignans, iridoids, flavonoids, polysaccharides, terpenes, and proteins, Liu et al.
(2012).
Lignans, the main bioactive components, were protective against hypertensive renal injury in spontaneous hypertensive rats in our previous study, Li et al.
(2012).
Moreover, Eucommia lignans also diminished aldose reductase (AR) overexpression in the kidney, Li et al.
(2012).
However, the pathological mechanism underlying the protective effects of Eucommia lignans remains unknown.
Cellular proliferation was reported to contribute to important pathological changes in hypertensive renal injuries, and increased angiotensin II (Ang II) expression was reported to be essential for target-organ damage during hypertension.
Ang II is the main effective peptide in the renin-angiotensin system and is considered to be a key mediator in the development of hypertensive nephropathy, Rüster and Wolf (2011).
Our preliminary results showed that Eucommia lignans had inhibitory effects on Ang II-induced proliferation of rat mesangial cells.
In the present study, we investigated the effects of Eucommia ulmoides on Ang II-induced proliferation and apoptosis of rat mesangial cells.
Cell cycle-related genes P21 and P27, and cell apoptosis-related genes Bax and Bcl-2, were determined.
American Psychological Association (APA)
Jing, Xian& Huang, Wei-Hua& Tang, Yong-Jun& Wang, Ya-Qin& Li, Hui& Tian, Ying-Ying…[et al.]. 2015. Eucommia ulmoides Oliv. (Du-Zhong) Lignans Inhibit Angiotensin II-Stimulated Proliferation by Affecting P21, P27, and Bax Expression in Rat Mesangial Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063871
Modern Language Association (MLA)
Jing, Xian…[et al.]. Eucommia ulmoides Oliv. (Du-Zhong) Lignans Inhibit Angiotensin II-Stimulated Proliferation by Affecting P21, P27, and Bax Expression in Rat Mesangial Cells. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063871
American Medical Association (AMA)
Jing, Xian& Huang, Wei-Hua& Tang, Yong-Jun& Wang, Ya-Qin& Li, Hui& Tian, Ying-Ying…[et al.]. Eucommia ulmoides Oliv. (Du-Zhong) Lignans Inhibit Angiotensin II-Stimulated Proliferation by Affecting P21, P27, and Bax Expression in Rat Mesangial Cells. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063871