Costus afer Possesses Carbohydrate Hydrolyzing Enzymes Inhibitory Activity and Antioxidant Capacity In Vitro
المؤلفون المشاركون
Tchokouaha Yamthe, Lauve Rachel
Tchamgoue, Armelle D.
Kuiate, Jules-Roger
Arrey Tarkang, Protus
Agbor, Gabriel Agbor
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Diabetes mellitus is a metabolic disorder of glucose metabolism which correlates with postprandial hyperglycemia and oxidative stress.
Control of blood glucose level is imperative in the management of diabetes.
The present study tested the hypothesis that Costus afer, an antihyperglycemic medicinal plant, possesses inhibitory activity against carbohydrate hydrolyzing enzymes.
Hexane, ethyl acetate, methanol, and water extracts were prepared from the leaf, stem, and rhizome of C.
afer and subjected to phytochemical screening, assayed for α-amylase and α-glucosidase inhibitory activities and antioxidant capacity (determined by total phenolic and total flavonoids contents, ferric reducing antioxidant power (FRAP), and DPPH radical scavenging activity).
All extracts inhibited α-amylase and α-glucosidase activities.
Ethyl acetate rhizome and methanol leaf extracts exhibited the best inhibitory activity against α-amylase and α-glucosidase (IC50: 0.10 and 5.99 mg/mL), respectively.
Kinetic analysis revealed two modes of enzyme inhibition (competitive and mixed).
All extracts showed antioxidant capacity, with hexane extracts exhibiting the best activity.
DPPH assay revealed that methanol leaf, rhizome, and ethyl acetate stem extracts (IC50 < 5 mg/mL) were the best antioxidants.
The presence of bioactive compounds such as flavonoids, alkaloids, phenols, and tannins may account for the antioxidant capacity and carbohydrate hydrolyzing enzyme inhibitory activity of C.
afer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tchamgoue, Armelle D.& Tchokouaha Yamthe, Lauve Rachel & Arrey Tarkang, Protus& Kuiate, Jules-Roger& Agbor, Gabriel Agbor. 2015. Costus afer Possesses Carbohydrate Hydrolyzing Enzymes Inhibitory Activity and Antioxidant Capacity In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063873
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tchamgoue, Armelle D.…[et al.]. Costus afer Possesses Carbohydrate Hydrolyzing Enzymes Inhibitory Activity and Antioxidant Capacity In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063873
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tchamgoue, Armelle D.& Tchokouaha Yamthe, Lauve Rachel & Arrey Tarkang, Protus& Kuiate, Jules-Roger& Agbor, Gabriel Agbor. Costus afer Possesses Carbohydrate Hydrolyzing Enzymes Inhibitory Activity and Antioxidant Capacity In Vitro. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063873
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063873
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر