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Costus afer Possesses Carbohydrate Hydrolyzing Enzymes Inhibitory Activity and Antioxidant Capacity In Vitro
Joint Authors
Tchokouaha Yamthe, Lauve Rachel
Tchamgoue, Armelle D.
Kuiate, Jules-Roger
Arrey Tarkang, Protus
Agbor, Gabriel Agbor
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetes mellitus is a metabolic disorder of glucose metabolism which correlates with postprandial hyperglycemia and oxidative stress.
Control of blood glucose level is imperative in the management of diabetes.
The present study tested the hypothesis that Costus afer, an antihyperglycemic medicinal plant, possesses inhibitory activity against carbohydrate hydrolyzing enzymes.
Hexane, ethyl acetate, methanol, and water extracts were prepared from the leaf, stem, and rhizome of C.
afer and subjected to phytochemical screening, assayed for α-amylase and α-glucosidase inhibitory activities and antioxidant capacity (determined by total phenolic and total flavonoids contents, ferric reducing antioxidant power (FRAP), and DPPH radical scavenging activity).
All extracts inhibited α-amylase and α-glucosidase activities.
Ethyl acetate rhizome and methanol leaf extracts exhibited the best inhibitory activity against α-amylase and α-glucosidase (IC50: 0.10 and 5.99 mg/mL), respectively.
Kinetic analysis revealed two modes of enzyme inhibition (competitive and mixed).
All extracts showed antioxidant capacity, with hexane extracts exhibiting the best activity.
DPPH assay revealed that methanol leaf, rhizome, and ethyl acetate stem extracts (IC50 < 5 mg/mL) were the best antioxidants.
The presence of bioactive compounds such as flavonoids, alkaloids, phenols, and tannins may account for the antioxidant capacity and carbohydrate hydrolyzing enzyme inhibitory activity of C.
afer.
American Psychological Association (APA)
Tchamgoue, Armelle D.& Tchokouaha Yamthe, Lauve Rachel & Arrey Tarkang, Protus& Kuiate, Jules-Roger& Agbor, Gabriel Agbor. 2015. Costus afer Possesses Carbohydrate Hydrolyzing Enzymes Inhibitory Activity and Antioxidant Capacity In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063873
Modern Language Association (MLA)
Tchamgoue, Armelle D.…[et al.]. Costus afer Possesses Carbohydrate Hydrolyzing Enzymes Inhibitory Activity and Antioxidant Capacity In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063873
American Medical Association (AMA)
Tchamgoue, Armelle D.& Tchokouaha Yamthe, Lauve Rachel & Arrey Tarkang, Protus& Kuiate, Jules-Roger& Agbor, Gabriel Agbor. Costus afer Possesses Carbohydrate Hydrolyzing Enzymes Inhibitory Activity and Antioxidant Capacity In Vitro. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063873