Molecular Features and Methylation Status in Early Onset (≤40 Years) Colorectal Cancer: A Population Based, Case-Control Study
المؤلفون المشاركون
Magnani, Giulia
Furlan, Daniela
Sahnane, Nora
Reggiani Bonetti, Luca
Domati, Federica
Pedroni, Monica
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Colorectal cancer is usually considered a disease of the elderly.
However, a small fraction of patients develops colorectal cancer earlier.
The aim of our study was to define the frequency of known hereditary colorectal syndromes and to characterise genetic and epigenetic features of early nonhereditary tumors.
Thirty-three patients ≤40 years with diagnosis of colorectal cancer and 41 patients with disease at >60 years of age were investigated for MSI, Mismatch Repair proteins expression, KRAS and BRAF mutations, hypermethylation, and LINE-1 hypomethylation.
Detection of germline mutations was performed in Mismatch Repair, APC and MUTYH genes.
Early onset colorectal cancer showed a high incidence of hereditary forms (18%).
KRAS mutations were detected in 36% of early nonhereditary tumors.
Early onset colorectal cancer disclosed an average number of methylated genes significantly lower when compared to the controls (p=0.02).
Finally both of the two groups were highly methylated in ESR1, GATA5, and WT1 genes and were similar for LINE-1 hypomethylation.
The genetic make-up of carcinomas differs from young to elderly patients.
Early onset tumors showed more frequently a constitutional defective of Mismatch Repair System and a minor number of methylated genes.
Hypermethylation of ESR1, GATA5, and WT1 genes suggests possible markers in the earlier diagnosis of colorectal tumorigenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Magnani, Giulia& Furlan, Daniela& Sahnane, Nora& Reggiani Bonetti, Luca& Domati, Federica& Pedroni, Monica. 2015. Molecular Features and Methylation Status in Early Onset (≤40 Years) Colorectal Cancer: A Population Based, Case-Control Study. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063919
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Magnani, Giulia…[et al.]. Molecular Features and Methylation Status in Early Onset (≤40 Years) Colorectal Cancer: A Population Based, Case-Control Study. Gastroenterology Research and Practice No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063919
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Magnani, Giulia& Furlan, Daniela& Sahnane, Nora& Reggiani Bonetti, Luca& Domati, Federica& Pedroni, Monica. Molecular Features and Methylation Status in Early Onset (≤40 Years) Colorectal Cancer: A Population Based, Case-Control Study. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063919
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063919
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر