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Current Review of Genetically Modified Lactic Acid Bacteria for the Prevention and Treatment of Colitis Using Murine Models
المؤلفون المشاركون
del Carmen, Silvina
Miyoshi, Anderson
Chatel, Jean-Marc
Bermúdez-Humarán, Luis G.
Azevedo, Vasco
Langella, Philippe
de Moreno de LeBlanc, Alejandra
LeBlanc, Jean Guy
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Inflammatory Bowel Diseases (IBD) are disorders of the gastrointestinal tract characterized by recurrent inflammation that requires lifelong treatments.
Probiotic microorganisms appear as an alternative for these patients; however, probiotic characteristics are strain dependent and each probiotic needs to be tested to understand the underlining mechanisms involved in their beneficial properties.
Genetic modification of lactic acid bacteria (LAB) was also described as a tool for new IBD treatments.
The first part of this review shows different genetically modified LAB (GM-LAB) described for IBD treatment since 2000.
Then, the two principally studied strategies are discussed (i) GM-LAB producing antioxidant enzymes and (ii) GM-LAB producing the anti-inflammatory cytokine IL-10.
Different delivery systems, including protein delivery and DNA delivery, will also be discussed.
Studies show the efficacy of GM-LAB (using different expression systems) for the prevention and treatment of IBD, highlighting the importance of the bacterial strain selection (with anti-inflammatory innate properties) as a promising alternative.
These microorganisms could be used in the near future for the development of therapeutic products with anti-inflammatory properties that can improve the quality of life of IBD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Moreno de LeBlanc, Alejandra& del Carmen, Silvina& Chatel, Jean-Marc& Miyoshi, Anderson& Azevedo, Vasco& Langella, Philippe…[et al.]. 2015. Current Review of Genetically Modified Lactic Acid Bacteria for the Prevention and Treatment of Colitis Using Murine Models. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063923
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Moreno de LeBlanc, Alejandra…[et al.]. Current Review of Genetically Modified Lactic Acid Bacteria for the Prevention and Treatment of Colitis Using Murine Models. Gastroenterology Research and Practice No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063923
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Moreno de LeBlanc, Alejandra& del Carmen, Silvina& Chatel, Jean-Marc& Miyoshi, Anderson& Azevedo, Vasco& Langella, Philippe…[et al.]. Current Review of Genetically Modified Lactic Acid Bacteria for the Prevention and Treatment of Colitis Using Murine Models. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063923
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063923
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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