Current Review of Genetically Modified Lactic Acid Bacteria for the Prevention and Treatment of Colitis Using Murine Models
Joint Authors
del Carmen, Silvina
Miyoshi, Anderson
Chatel, Jean-Marc
Bermúdez-Humarán, Luis G.
Azevedo, Vasco
Langella, Philippe
de Moreno de LeBlanc, Alejandra
LeBlanc, Jean Guy
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Inflammatory Bowel Diseases (IBD) are disorders of the gastrointestinal tract characterized by recurrent inflammation that requires lifelong treatments.
Probiotic microorganisms appear as an alternative for these patients; however, probiotic characteristics are strain dependent and each probiotic needs to be tested to understand the underlining mechanisms involved in their beneficial properties.
Genetic modification of lactic acid bacteria (LAB) was also described as a tool for new IBD treatments.
The first part of this review shows different genetically modified LAB (GM-LAB) described for IBD treatment since 2000.
Then, the two principally studied strategies are discussed (i) GM-LAB producing antioxidant enzymes and (ii) GM-LAB producing the anti-inflammatory cytokine IL-10.
Different delivery systems, including protein delivery and DNA delivery, will also be discussed.
Studies show the efficacy of GM-LAB (using different expression systems) for the prevention and treatment of IBD, highlighting the importance of the bacterial strain selection (with anti-inflammatory innate properties) as a promising alternative.
These microorganisms could be used in the near future for the development of therapeutic products with anti-inflammatory properties that can improve the quality of life of IBD patients.
American Psychological Association (APA)
de Moreno de LeBlanc, Alejandra& del Carmen, Silvina& Chatel, Jean-Marc& Miyoshi, Anderson& Azevedo, Vasco& Langella, Philippe…[et al.]. 2015. Current Review of Genetically Modified Lactic Acid Bacteria for the Prevention and Treatment of Colitis Using Murine Models. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063923
Modern Language Association (MLA)
de Moreno de LeBlanc, Alejandra…[et al.]. Current Review of Genetically Modified Lactic Acid Bacteria for the Prevention and Treatment of Colitis Using Murine Models. Gastroenterology Research and Practice No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063923
American Medical Association (AMA)
de Moreno de LeBlanc, Alejandra& del Carmen, Silvina& Chatel, Jean-Marc& Miyoshi, Anderson& Azevedo, Vasco& Langella, Philippe…[et al.]. Current Review of Genetically Modified Lactic Acid Bacteria for the Prevention and Treatment of Colitis Using Murine Models. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063923