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The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort
المؤلفون المشاركون
Krawczyk, Marcin
Liebe, Roman
Maier, Ina B.
Engstler, Anna Janina
Lammert, Frank
Bergheim, Ina
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-04
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
The common adiponutrin (PNPLA3) variant p.Ile148Met is associated with liver injury.
Here, we investigate the association of this polymorphism with hepatic and metabolic traits in a pediatric cohort.
Patients and Methods.
The study cohort comprised 142 German children (age 5–9 years, 98 overweight, 19 children with NAFLD).
Results.
Overweight children presented with increased serum ALT ( P = 0.001 ) and GGT ( P < 0.001 ) activities.
ALT activities differed significantly ( P = 0.02 ) between carriers of different PNPLA3 genotypes in the entire study cohort, in normal weight children ( P = 0.02 ) and in children younger than 7 years ( P = 0.02 ).
Carriers of the prosteatotic PNPLA3 genotype p.148Met/Met displayed higher ALT activities as compared to children with the frequent genotype p.148Ile/Ile ( P = 0.01 ).
The BMI was however a stronger predictor of ALT activities compared to the PNPLA3 genotype ( P < 0.001 and P = 0.06 , resp.).
The variant was associated with increased serum glucose levels ( P = 0.01 ) and HOMA index ( P = 0.02 ) in carriers of the p.148Ile/Met genotype but did not affect other metabolic traits or the presence of NAFLD.
Discussion.
The frequent PNPLA3 variant p.Ile148Met is associated with serum ALT activities already at a young age.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Krawczyk, Marcin& Liebe, Roman& Maier, Ina B.& Engstler, Anna Janina& Lammert, Frank& Bergheim, Ina. 2015. The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063932
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Krawczyk, Marcin…[et al.]. The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort. Gastroenterology Research and Practice No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1063932
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Krawczyk, Marcin& Liebe, Roman& Maier, Ina B.& Engstler, Anna Janina& Lammert, Frank& Bergheim, Ina. The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063932
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063932
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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