The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort
Joint Authors
Krawczyk, Marcin
Liebe, Roman
Maier, Ina B.
Engstler, Anna Janina
Lammert, Frank
Bergheim, Ina
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
The common adiponutrin (PNPLA3) variant p.Ile148Met is associated with liver injury.
Here, we investigate the association of this polymorphism with hepatic and metabolic traits in a pediatric cohort.
Patients and Methods.
The study cohort comprised 142 German children (age 5–9 years, 98 overweight, 19 children with NAFLD).
Results.
Overweight children presented with increased serum ALT ( P = 0.001 ) and GGT ( P < 0.001 ) activities.
ALT activities differed significantly ( P = 0.02 ) between carriers of different PNPLA3 genotypes in the entire study cohort, in normal weight children ( P = 0.02 ) and in children younger than 7 years ( P = 0.02 ).
Carriers of the prosteatotic PNPLA3 genotype p.148Met/Met displayed higher ALT activities as compared to children with the frequent genotype p.148Ile/Ile ( P = 0.01 ).
The BMI was however a stronger predictor of ALT activities compared to the PNPLA3 genotype ( P < 0.001 and P = 0.06 , resp.).
The variant was associated with increased serum glucose levels ( P = 0.01 ) and HOMA index ( P = 0.02 ) in carriers of the p.148Ile/Met genotype but did not affect other metabolic traits or the presence of NAFLD.
Discussion.
The frequent PNPLA3 variant p.Ile148Met is associated with serum ALT activities already at a young age.
American Psychological Association (APA)
Krawczyk, Marcin& Liebe, Roman& Maier, Ina B.& Engstler, Anna Janina& Lammert, Frank& Bergheim, Ina. 2015. The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063932
Modern Language Association (MLA)
Krawczyk, Marcin…[et al.]. The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort. Gastroenterology Research and Practice No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1063932
American Medical Association (AMA)
Krawczyk, Marcin& Liebe, Roman& Maier, Ina B.& Engstler, Anna Janina& Lammert, Frank& Bergheim, Ina. The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063932
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063932