The Genetic Predisposition and Its Impact on the Diabetes Mellitus Development in Patients with Alcoholic Chronic Pancreatitis
المؤلفون المشاركون
Madro, Agnieszka
Ciesielka, Marzanna
Slomka, Maria
Czechowska, Grazyna
Kurzepa, Jacek
Buszewicz, Grzegorz
Madro, Roman
Kasztelan-Szczerbinska, Beata
Celinski, Krzysztof
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-09
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The most common cause of chronic pancreatitis (CP) is alcohol abuse.
The aim of the present study was to identify patients with genetic predisposition to CP abusing alcohol.
The question posed was whether CP manifests at a younger age and diabetes mellitus develops earlier in individuals with genetic predisposition.
The study encompassed 79 patients with alcoholic chronic pancreatitis (ACP) and control group (100 persons).
The following mutations were determined: R122H and N29I of PRSS1 and N34S of SPINK1 as well as E366K and E288V of SERPINA 1.
No R122H and N291 mutations were observed in the group of ACP patients and in controls.
Moreover, there was no E288V mutation.
In 79 ACP patients, six SPINK 1 (N34S/wt) mutations were observed.
In the control group, one heterozygous SPINK 1N34S gene mutation was found (P=0.0238).
Two PiZ mutations were identified in patients with ACP and one analogical mutation in controls.
Amongst patients with ACP as well as SPINK1 and PiZ mutations, the onset of disease was observed earlier and developed earlier.
The prevalence of SPINK1 mutation is higher in patients with ACP than in healthy populations.
This mutation together with the effects of alcohol accelerates the development of ACP and of diabetes mellitus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Madro, Agnieszka& Ciesielka, Marzanna& Celinski, Krzysztof& Slomka, Maria& Czechowska, Grazyna& Kurzepa, Jacek…[et al.]. 2015. The Genetic Predisposition and Its Impact on the Diabetes Mellitus Development in Patients with Alcoholic Chronic Pancreatitis. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1063955
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Madro, Agnieszka…[et al.]. The Genetic Predisposition and Its Impact on the Diabetes Mellitus Development in Patients with Alcoholic Chronic Pancreatitis. Gastroenterology Research and Practice No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1063955
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Madro, Agnieszka& Ciesielka, Marzanna& Celinski, Krzysztof& Slomka, Maria& Czechowska, Grazyna& Kurzepa, Jacek…[et al.]. The Genetic Predisposition and Its Impact on the Diabetes Mellitus Development in Patients with Alcoholic Chronic Pancreatitis. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1063955
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063955
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر