The Genetic Predisposition and Its Impact on the Diabetes Mellitus Development in Patients with Alcoholic Chronic Pancreatitis
Joint Authors
Madro, Agnieszka
Ciesielka, Marzanna
Slomka, Maria
Czechowska, Grazyna
Kurzepa, Jacek
Buszewicz, Grzegorz
Madro, Roman
Kasztelan-Szczerbinska, Beata
Celinski, Krzysztof
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The most common cause of chronic pancreatitis (CP) is alcohol abuse.
The aim of the present study was to identify patients with genetic predisposition to CP abusing alcohol.
The question posed was whether CP manifests at a younger age and diabetes mellitus develops earlier in individuals with genetic predisposition.
The study encompassed 79 patients with alcoholic chronic pancreatitis (ACP) and control group (100 persons).
The following mutations were determined: R122H and N29I of PRSS1 and N34S of SPINK1 as well as E366K and E288V of SERPINA 1.
No R122H and N291 mutations were observed in the group of ACP patients and in controls.
Moreover, there was no E288V mutation.
In 79 ACP patients, six SPINK 1 (N34S/wt) mutations were observed.
In the control group, one heterozygous SPINK 1N34S gene mutation was found (P=0.0238).
Two PiZ mutations were identified in patients with ACP and one analogical mutation in controls.
Amongst patients with ACP as well as SPINK1 and PiZ mutations, the onset of disease was observed earlier and developed earlier.
The prevalence of SPINK1 mutation is higher in patients with ACP than in healthy populations.
This mutation together with the effects of alcohol accelerates the development of ACP and of diabetes mellitus.
American Psychological Association (APA)
Madro, Agnieszka& Ciesielka, Marzanna& Celinski, Krzysztof& Slomka, Maria& Czechowska, Grazyna& Kurzepa, Jacek…[et al.]. 2015. The Genetic Predisposition and Its Impact on the Diabetes Mellitus Development in Patients with Alcoholic Chronic Pancreatitis. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1063955
Modern Language Association (MLA)
Madro, Agnieszka…[et al.]. The Genetic Predisposition and Its Impact on the Diabetes Mellitus Development in Patients with Alcoholic Chronic Pancreatitis. Gastroenterology Research and Practice No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1063955
American Medical Association (AMA)
Madro, Agnieszka& Ciesielka, Marzanna& Celinski, Krzysztof& Slomka, Maria& Czechowska, Grazyna& Kurzepa, Jacek…[et al.]. The Genetic Predisposition and Its Impact on the Diabetes Mellitus Development in Patients with Alcoholic Chronic Pancreatitis. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1063955
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063955