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Hepatorenal Syndrome: Outcome of Response to Therapy and Predictors of Survival
المؤلفون المشاركون
Heidemann, Jan
Bartels, Christoph
Berssenbrügge, Christoph
Schmidt, Hartmut
Meister, Tobias
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
Treatment of hepatorenal syndrome (HRS) in patients with liver cirrhosis is still challenging and characterized by a very high mortality.
This study aimed to delineate treatment patterns and clinical outcomes of patients with HRS intravenously treated with terlipressin.
Methods.
In this retrospective single-center cohort study, 119 patients (median [IQR]; 56.50 [50.75–63.00] years of age) with HRS were included.
All patients were treated with terlipressin and human albumin intravenously.
Those with response to treatment ( n = 65 ) were compared to the patient cohort without improvement ( n = 54 ).
Patient characteristics and clinical parameters (Child stage, ascites, hepatic encephalopathy, HRS type I/II, and initial MELD score) were retrieved.
Univariate analysis of factors influencing the success of terlipressin therapy and Cox regression analysis of factors influencing survival was carried out.
Results.
One-month survival was significantly longer in the group of responders ( p = 0.048 ).
Cox regression analysis identified age [Hazard ratio, 95% confidence interval (CI); 1.05, 1.01–1.09, resp.], alcohol abuse [HR 3.05, 95% CI 1.11–8.38], duration of treatment [HR 0.92, 95% CI 0.88–0.96], and MELD score [HR 1.08, 95% CI 1.02–1.14] to be independent predictors of survival.
Conclusions.
Survival of HRS patients after treatment depends on age, etiology of liver disease, and the duration of treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Heidemann, Jan& Bartels, Christoph& Berssenbrügge, Christoph& Schmidt, Hartmut& Meister, Tobias. 2015. Hepatorenal Syndrome: Outcome of Response to Therapy and Predictors of Survival. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063987
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Heidemann, Jan…[et al.]. Hepatorenal Syndrome: Outcome of Response to Therapy and Predictors of Survival. Gastroenterology Research and Practice No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063987
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Heidemann, Jan& Bartels, Christoph& Berssenbrügge, Christoph& Schmidt, Hartmut& Meister, Tobias. Hepatorenal Syndrome: Outcome of Response to Therapy and Predictors of Survival. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063987
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1063987
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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