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Hepatorenal Syndrome: Outcome of Response to Therapy and Predictors of Survival
Joint Authors
Heidemann, Jan
Bartels, Christoph
Berssenbrügge, Christoph
Schmidt, Hartmut
Meister, Tobias
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
Treatment of hepatorenal syndrome (HRS) in patients with liver cirrhosis is still challenging and characterized by a very high mortality.
This study aimed to delineate treatment patterns and clinical outcomes of patients with HRS intravenously treated with terlipressin.
Methods.
In this retrospective single-center cohort study, 119 patients (median [IQR]; 56.50 [50.75–63.00] years of age) with HRS were included.
All patients were treated with terlipressin and human albumin intravenously.
Those with response to treatment ( n = 65 ) were compared to the patient cohort without improvement ( n = 54 ).
Patient characteristics and clinical parameters (Child stage, ascites, hepatic encephalopathy, HRS type I/II, and initial MELD score) were retrieved.
Univariate analysis of factors influencing the success of terlipressin therapy and Cox regression analysis of factors influencing survival was carried out.
Results.
One-month survival was significantly longer in the group of responders ( p = 0.048 ).
Cox regression analysis identified age [Hazard ratio, 95% confidence interval (CI); 1.05, 1.01–1.09, resp.], alcohol abuse [HR 3.05, 95% CI 1.11–8.38], duration of treatment [HR 0.92, 95% CI 0.88–0.96], and MELD score [HR 1.08, 95% CI 1.02–1.14] to be independent predictors of survival.
Conclusions.
Survival of HRS patients after treatment depends on age, etiology of liver disease, and the duration of treatment.
American Psychological Association (APA)
Heidemann, Jan& Bartels, Christoph& Berssenbrügge, Christoph& Schmidt, Hartmut& Meister, Tobias. 2015. Hepatorenal Syndrome: Outcome of Response to Therapy and Predictors of Survival. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063987
Modern Language Association (MLA)
Heidemann, Jan…[et al.]. Hepatorenal Syndrome: Outcome of Response to Therapy and Predictors of Survival. Gastroenterology Research and Practice No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063987
American Medical Association (AMA)
Heidemann, Jan& Bartels, Christoph& Berssenbrügge, Christoph& Schmidt, Hartmut& Meister, Tobias. Hepatorenal Syndrome: Outcome of Response to Therapy and Predictors of Survival. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063987