TLR3 Plays Significant Roles against HBV-Associated HCC
المؤلفون المشاركون
Chen, Xiaolan
Xu, Yu-yin
Shen, Yin
Wang, Gui-lan
Chen, Li
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Toll-like receptor 3 (TLR3) is a pattern-recognizing receptor that is involved in immune signaling and plays a crucial role in survival by being able to recognize various viral components including double-stranded RNA (dsRNA).
The role of TLR3 in hepatocellular carcinoma (HCC) with hepatitis B virus (HBV) infections is not well understood.
To investigate the ability of TLR3 in regulating HBV replication in HCC, 80 cases of human HCC were collected and their tissue microarray was made.
In HCC cells, the expression and location of TLR3, hepatitis-associated virus, and interstitial immunoreactive cells were assayed with immunohistochemical staining.
The apoptosis of tumor cells was also detected by TUNEL stain.
Correlations between TLR3 expression and HBV infection, interstitial immunoreactive cells, and cells apoptosis in HCC were investigated.
In addition, we explored whether TLR3 agonist dsRNA can inhibit HepG2.2.15 cells secreting HBV.
We found that the cytoplasmic expression of TLR3 in HCC is positively related to HBsAg infection and HCC with cirrhosis and promotes interstitial immunoreactive cells infiltration and cancer cells apoptosis.
In HepG2.2.15 cells, dsRNA inhibited the secretion of HBV and induced apoptosis.
These results indicate that TLR3 signaling activity may be involved in immune responses against HBV in HCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Xiaolan& Xu, Yu-yin& Chen, Li& Wang, Gui-lan& Shen, Yin. 2015. TLR3 Plays Significant Roles against HBV-Associated HCC. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1064056
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Xiaolan…[et al.]. TLR3 Plays Significant Roles against HBV-Associated HCC. Gastroenterology Research and Practice No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1064056
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Xiaolan& Xu, Yu-yin& Chen, Li& Wang, Gui-lan& Shen, Yin. TLR3 Plays Significant Roles against HBV-Associated HCC. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1064056
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1064056
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر