TLR3 Plays Significant Roles against HBV-Associated HCC
Joint Authors
Chen, Xiaolan
Xu, Yu-yin
Shen, Yin
Wang, Gui-lan
Chen, Li
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Toll-like receptor 3 (TLR3) is a pattern-recognizing receptor that is involved in immune signaling and plays a crucial role in survival by being able to recognize various viral components including double-stranded RNA (dsRNA).
The role of TLR3 in hepatocellular carcinoma (HCC) with hepatitis B virus (HBV) infections is not well understood.
To investigate the ability of TLR3 in regulating HBV replication in HCC, 80 cases of human HCC were collected and their tissue microarray was made.
In HCC cells, the expression and location of TLR3, hepatitis-associated virus, and interstitial immunoreactive cells were assayed with immunohistochemical staining.
The apoptosis of tumor cells was also detected by TUNEL stain.
Correlations between TLR3 expression and HBV infection, interstitial immunoreactive cells, and cells apoptosis in HCC were investigated.
In addition, we explored whether TLR3 agonist dsRNA can inhibit HepG2.2.15 cells secreting HBV.
We found that the cytoplasmic expression of TLR3 in HCC is positively related to HBsAg infection and HCC with cirrhosis and promotes interstitial immunoreactive cells infiltration and cancer cells apoptosis.
In HepG2.2.15 cells, dsRNA inhibited the secretion of HBV and induced apoptosis.
These results indicate that TLR3 signaling activity may be involved in immune responses against HBV in HCC.
American Psychological Association (APA)
Chen, Xiaolan& Xu, Yu-yin& Chen, Li& Wang, Gui-lan& Shen, Yin. 2015. TLR3 Plays Significant Roles against HBV-Associated HCC. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1064056
Modern Language Association (MLA)
Chen, Xiaolan…[et al.]. TLR3 Plays Significant Roles against HBV-Associated HCC. Gastroenterology Research and Practice No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1064056
American Medical Association (AMA)
Chen, Xiaolan& Xu, Yu-yin& Chen, Li& Wang, Gui-lan& Shen, Yin. TLR3 Plays Significant Roles against HBV-Associated HCC. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1064056
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064056