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Association between Virulence Factors and TRAF14-1BBBcl-xL Expression in Gastric Mucosa Infected with Helicobacter pylori
المؤلفون المشاركون
Wang, Fen
Wu, Xiang
Liu, Zhiying
Bu, Guangkui
Li, Xiayu
Qu, Nanfang
Peng, Jin
Xu, Canxia
Shen, Shourong
Yuan, Yi
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-08
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
CagA+/vacAs1+/vacAm1+ Helicobacter pylori upregulates the expression of tumor necrosis factor receptor–associated factor 1 (TRAF1), tumor necrosis factor receptor superfamily member 9 (4-1BB), and B-cell lymphoma-extra large (Bcl-xL) in human gastric epithelial cells.
We investigated the correlation between cagA/vacAs1/vacAm1 and TRAF1/4-1BB/Bcl-xL expression in gastric mucosal tissue of patients with gastric disorders.
Methods.
We collected gastric mucosa samples from 35 chronic, nonatrophic gastritis (CG) patients, 41 atrophic gastritis patients, 44 intestinal metaplasia with atypical hyperplasia (IM) patients, and 28 gastric carcinoma (Ca) patients.
The expression of TRAF1, 4-1BB, and Bcl-xL was determined using western blotting.
The expression of cagA, vacAs1, and vacAm1 in H.
pylori was examined with polymerase chain reaction.
Results.
The expression of TRAF1, 4-1BB, and Bcl-xL was significantly upregulated in IM and Ca patients ( P < 0.05 compared with CG).
There were more cases of cagA+/vacAs1+/vacAm1+ H.
pylori infection in samples with elevated TRAF1, 4-1BB, or Bcl-xL expression ( P < 0.05 ).
Additionally, there were a remarkably large number of samples with upregulated TRAF1/4-1BB/Bcl-xL expression in cases of cagA+/vacAs1+/vacAm1+ H.
pylori infection (44 cases, 67.7%; P < 0.05 ).
Conclusions.
The pathogenesis of IM and Ca may be promoted by cagA+/vacAs1+/vacAm1+ H.
pylori, possibly via upregulated TRAF1, 4-1BB, and Bcl-xL in gastric mucosal tissue.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Fen& Wu, Xiang& Liu, Zhiying& Bu, Guangkui& Li, Xiayu& Qu, Nanfang…[et al.]. 2015. Association between Virulence Factors and TRAF14-1BBBcl-xL Expression in Gastric Mucosa Infected with Helicobacter pylori. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1064076
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Fen…[et al.]. Association between Virulence Factors and TRAF14-1BBBcl-xL Expression in Gastric Mucosa Infected with Helicobacter pylori. Gastroenterology Research and Practice No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1064076
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Fen& Wu, Xiang& Liu, Zhiying& Bu, Guangkui& Li, Xiayu& Qu, Nanfang…[et al.]. Association between Virulence Factors and TRAF14-1BBBcl-xL Expression in Gastric Mucosa Infected with Helicobacter pylori. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1064076
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1064076
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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