Association between Virulence Factors and TRAF14-1BBBcl-xL Expression in Gastric Mucosa Infected with Helicobacter pylori
Joint Authors
Wang, Fen
Wu, Xiang
Liu, Zhiying
Bu, Guangkui
Li, Xiayu
Qu, Nanfang
Peng, Jin
Xu, Canxia
Shen, Shourong
Yuan, Yi
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
CagA+/vacAs1+/vacAm1+ Helicobacter pylori upregulates the expression of tumor necrosis factor receptor–associated factor 1 (TRAF1), tumor necrosis factor receptor superfamily member 9 (4-1BB), and B-cell lymphoma-extra large (Bcl-xL) in human gastric epithelial cells.
We investigated the correlation between cagA/vacAs1/vacAm1 and TRAF1/4-1BB/Bcl-xL expression in gastric mucosal tissue of patients with gastric disorders.
Methods.
We collected gastric mucosa samples from 35 chronic, nonatrophic gastritis (CG) patients, 41 atrophic gastritis patients, 44 intestinal metaplasia with atypical hyperplasia (IM) patients, and 28 gastric carcinoma (Ca) patients.
The expression of TRAF1, 4-1BB, and Bcl-xL was determined using western blotting.
The expression of cagA, vacAs1, and vacAm1 in H.
pylori was examined with polymerase chain reaction.
Results.
The expression of TRAF1, 4-1BB, and Bcl-xL was significantly upregulated in IM and Ca patients ( P < 0.05 compared with CG).
There were more cases of cagA+/vacAs1+/vacAm1+ H.
pylori infection in samples with elevated TRAF1, 4-1BB, or Bcl-xL expression ( P < 0.05 ).
Additionally, there were a remarkably large number of samples with upregulated TRAF1/4-1BB/Bcl-xL expression in cases of cagA+/vacAs1+/vacAm1+ H.
pylori infection (44 cases, 67.7%; P < 0.05 ).
Conclusions.
The pathogenesis of IM and Ca may be promoted by cagA+/vacAs1+/vacAm1+ H.
pylori, possibly via upregulated TRAF1, 4-1BB, and Bcl-xL in gastric mucosal tissue.
American Psychological Association (APA)
Wang, Fen& Wu, Xiang& Liu, Zhiying& Bu, Guangkui& Li, Xiayu& Qu, Nanfang…[et al.]. 2015. Association between Virulence Factors and TRAF14-1BBBcl-xL Expression in Gastric Mucosa Infected with Helicobacter pylori. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1064076
Modern Language Association (MLA)
Wang, Fen…[et al.]. Association between Virulence Factors and TRAF14-1BBBcl-xL Expression in Gastric Mucosa Infected with Helicobacter pylori. Gastroenterology Research and Practice No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1064076
American Medical Association (AMA)
Wang, Fen& Wu, Xiang& Liu, Zhiying& Bu, Guangkui& Li, Xiayu& Qu, Nanfang…[et al.]. Association between Virulence Factors and TRAF14-1BBBcl-xL Expression in Gastric Mucosa Infected with Helicobacter pylori. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1064076
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064076