The Increased Expression of CCL20 and CCR6 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis
المؤلفون المشاركون
Uchida, Keiichi
Saigusa, Susumu
Matsushita, Kohei
Hashimoto, Kiyoshi
Inoue, Mikihiro
Otake, Kohei
Okita, Yoshiki
Fujikawa, Hiroyuki
Mohri, Yasuhiko
Kusunoki, Masato
Araki, Toshimitsu
Tanaka, Koji
Koike, Yuhki
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-27
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background/Aims.
The aim of this study is to clarify the differences of CCL20 and CCR6 expression, chemokine correlated to intestinal homeostasis, between pediatric and adult ulcerative colitis (UC) patients.
Methods.
Onehundred forty-one patients who underwent proctocolectomy were divided to two groups including childhood-onset UC (CUC, < 16 years old, n = 24 ) and adult-onset UC (AUC, ≧ 16 years old, n = 117 ) .
A total of 141 formalin-fixed, paraffin-embedded tissue samples of rectum were obtained from these patients.
Histological inflammation of rectum in resected specimen was evaluated by using Geboes histological assessment.
In immunohistochemistry study, the CCL20 expression was evaluated by intensity and the stained area, and the CCR6 expression was evaluated by lymphocytes infiltration pattern.
Results.
CCL20 score and CCR6 positive lymphocytes infiltration pattern were statistically significantly correlated with histological inflammation severity of UC in all patients ( P < 0.05 ) .
CCL20 and CCR6 expression in CUC were statistically significantly higher than that in AUC in all or pathologically severe cases ( P < 0.05 ) .
Conclusions.
CCL20 and CCR6 may play a significant role in local damage and pathological changes in UC especially pediatric patients.
In the future, our understanding of the differences in CCL-CCR6 interaction between adults and children may lead to the pathogenesis of IBD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Uchida, Keiichi& Koike, Yuhki& Hashimoto, Kiyoshi& Saigusa, Susumu& Inoue, Mikihiro& Otake, Kohei…[et al.]. 2015. The Increased Expression of CCL20 and CCR6 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1064138
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Uchida, Keiichi…[et al.]. The Increased Expression of CCL20 and CCR6 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis. Gastroenterology Research and Practice No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1064138
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Uchida, Keiichi& Koike, Yuhki& Hashimoto, Kiyoshi& Saigusa, Susumu& Inoue, Mikihiro& Otake, Kohei…[et al.]. The Increased Expression of CCL20 and CCR6 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1064138
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1064138
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر