The Increased Expression of CCL20 and CCR6 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis
Joint Authors
Uchida, Keiichi
Saigusa, Susumu
Matsushita, Kohei
Hashimoto, Kiyoshi
Inoue, Mikihiro
Otake, Kohei
Okita, Yoshiki
Fujikawa, Hiroyuki
Mohri, Yasuhiko
Kusunoki, Masato
Araki, Toshimitsu
Tanaka, Koji
Koike, Yuhki
Source
Gastroenterology Research and Practice
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background/Aims.
The aim of this study is to clarify the differences of CCL20 and CCR6 expression, chemokine correlated to intestinal homeostasis, between pediatric and adult ulcerative colitis (UC) patients.
Methods.
Onehundred forty-one patients who underwent proctocolectomy were divided to two groups including childhood-onset UC (CUC, < 16 years old, n = 24 ) and adult-onset UC (AUC, ≧ 16 years old, n = 117 ) .
A total of 141 formalin-fixed, paraffin-embedded tissue samples of rectum were obtained from these patients.
Histological inflammation of rectum in resected specimen was evaluated by using Geboes histological assessment.
In immunohistochemistry study, the CCL20 expression was evaluated by intensity and the stained area, and the CCR6 expression was evaluated by lymphocytes infiltration pattern.
Results.
CCL20 score and CCR6 positive lymphocytes infiltration pattern were statistically significantly correlated with histological inflammation severity of UC in all patients ( P < 0.05 ) .
CCL20 and CCR6 expression in CUC were statistically significantly higher than that in AUC in all or pathologically severe cases ( P < 0.05 ) .
Conclusions.
CCL20 and CCR6 may play a significant role in local damage and pathological changes in UC especially pediatric patients.
In the future, our understanding of the differences in CCL-CCR6 interaction between adults and children may lead to the pathogenesis of IBD.
American Psychological Association (APA)
Uchida, Keiichi& Koike, Yuhki& Hashimoto, Kiyoshi& Saigusa, Susumu& Inoue, Mikihiro& Otake, Kohei…[et al.]. 2015. The Increased Expression of CCL20 and CCR6 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1064138
Modern Language Association (MLA)
Uchida, Keiichi…[et al.]. The Increased Expression of CCL20 and CCR6 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis. Gastroenterology Research and Practice No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1064138
American Medical Association (AMA)
Uchida, Keiichi& Koike, Yuhki& Hashimoto, Kiyoshi& Saigusa, Susumu& Inoue, Mikihiro& Otake, Kohei…[et al.]. The Increased Expression of CCL20 and CCR6 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1064138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064138