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Inhibitory Effect of Endostar on Specific Angiogenesis Induced by Human Hepatocellular Carcinoma
المؤلفون المشاركون
Qin, Shukui
Ye, Qing
Liu, Yanhong
Feng, Jundong
Wu, Qiong
Qu, Wenshu
Yin, Xiaojin
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
To investigate the effect of endostar on specific angiogenesis induced by human hepatocellular carcinoma, this research systematically elucidated the inhibitory effect on HepG2-induced angiogenesis by endostar from 50 ng/mL to 50000 ng/mL.
We employed fluorescence quantitative Boyden chamber analysis, wound-healing assay, flow cytometry examination using a coculture system, quantitative analysis of tube formation, and in vivo Matrigel plug assay induced by HCC conditioned media (HCM) and HepG2 compared with normal hepatocyte conditioned media (NCM) and L02.
Then, we found that endostar as a tumor angiogenesis inhibitor could potently inhibit human umbilical vein endothelial cell (HUVEC) migration in response to HCM after four- to six-hour action, inhibit HCM-induced HUVEC migration to the lesion part in a dose-dependent manner between 50 ng/mL and 5000 ng/mL at 24 hours, and reduce HUVEC proliferation in a dose-dependent fashion.
Endostar inhibited HepG2-induced tube formation of HUVECs which peaked at 50 ng/mL.
In vivo Matrigel plug formation was also significantly reduced by endostar in HepG2 inducing system rather than in L02 inducing system.
It could be concluded that, at cell level, endostar inhibited the angiogenesis-related biological behaviors of HUVEC in response to HCC, including migration, adhesion proliferation, and tube formation.
At animal level, endostar inhibited the angiogenesis in response to HCC in Matrigel matrix.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ye, Qing& Qin, Shukui& Feng, Jundong& Wu, Qiong& Qu, Wenshu& Yin, Xiaojin…[et al.]. 2015. Inhibitory Effect of Endostar on Specific Angiogenesis Induced by Human Hepatocellular Carcinoma. Gastroenterology Research and Practice،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1064364
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Feng, Jundong…[et al.]. Inhibitory Effect of Endostar on Specific Angiogenesis Induced by Human Hepatocellular Carcinoma. Gastroenterology Research and Practice No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1064364
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ye, Qing& Qin, Shukui& Feng, Jundong& Wu, Qiong& Qu, Wenshu& Yin, Xiaojin…[et al.]. Inhibitory Effect of Endostar on Specific Angiogenesis Induced by Human Hepatocellular Carcinoma. Gastroenterology Research and Practice. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1064364
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1064364
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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