![](/images/graphics-bg.png)
Stability-Indicating HPLC Determination of Trandolapril in Bulk Drug and Pharmaceutical Dosage Forms
المؤلفون المشاركون
Al-Hawash, Leena A.
Shakya, Ashok K.
Saleem, Maher L.
المصدر
International Journal of Analytical Chemistry
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
A rapid, simple, accurate, precise, economical, robust, and stability indicating reverse phase HPLC-PDA procedure has been developed and validated for the determination of trandolapril.
The trandolapril was separated isocratically on Hypersil-Gold C18 column (250 mm × 4.6 mm, 5 μm) with a mobile phase consisting of 50% acetonitrile and 50% water (containing 0.025% triethylamine, pH 3.0 ± 0.1 ), at 25 ± 2 °C.
Retention time of the drug was ~4.6 min.
The eluted compounds were monitored and identified at 210 nm.
The linearity of the method was excellent ( r 2 > 0.9999 ) over the concentration range of 1–24 μg/mL; the limit of detection (LOD) and limit of quantitation (LOQ) were 0.0566 μg/mL and 0.1715 μg/mL, respectively.
The overall precision was less than 2%.
Mean recovery of trandolapril was more than 99%; no interference was found from the component present in the preparation.
Stability studies indicate that the drug was stable to sunlight and UV light.
The drug gives 6 different oxidative products on exposure to hydrogen peroxide.
Slight degradation was observed in acidic condition.
Degradation was higher in the alkaline condition compared to other conditions.
The robustness of the method was studied using factorial design experiment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Al-Hawash, Leena A.& Shakya, Ashok K.& Saleem, Maher L.. 2015. Stability-Indicating HPLC Determination of Trandolapril in Bulk Drug and Pharmaceutical Dosage Forms. International Journal of Analytical Chemistry،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1064447
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Al-Hawash, Leena A.…[et al.]. Stability-Indicating HPLC Determination of Trandolapril in Bulk Drug and Pharmaceutical Dosage Forms. International Journal of Analytical Chemistry No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1064447
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Al-Hawash, Leena A.& Shakya, Ashok K.& Saleem, Maher L.. Stability-Indicating HPLC Determination of Trandolapril in Bulk Drug and Pharmaceutical Dosage Forms. International Journal of Analytical Chemistry. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1064447
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1064447
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)