Beneficial Effects of Teucrium polium and Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats
المؤلفون المشاركون
Sadeghnia, Hamid Reza
Hassanzadeh, Zarha
Keshavarzi, Zakieh
Mousavi, Seyed Mojtaba
Niazmand, Saeed
Hosseini, Mahmoud
Vafaee Bagheri, Farzaneh
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
The effects of hydroalcoholic extract of Teucrium polium and metformin on diabetes-induced memory impairment and brain tissues oxidative damage were investigated.
Methods.
The rats were divided into: (1) Control, (2) Diabetic, (3) Diabetic-Extract 100 (Dia-Ext 100), (4) Diabetic-Extract 200 (Dia-Ext 200), (5) Diabetic-Extract 400 (Dia-Ext 400), and (6) Diabetic-Metformin (Dia-Met).
Groups 3–6 were treated by 100, 200, and 400 mg/kg of the extract or metformin, respectively, for 6 weeks (orally).
Results.
In passive avoidance test, the latency to enter the dark compartment in Diabetic group was lower than that of Control group ( P < 0.01 ).
In Dia-Ext 100, Dia-Ext 200, and Dia-Ext 400 and Metformin groups, the latencies were higher than those of Diabetic group ( P < 0.01 ).
Lipid peroxides levels (reported as malondialdehyde, MDA, concentration) in the brain of Diabetic group were higher than Control ( P < 0.001 ).
Treatment by all doses of the extract and metformin decreased the MDA concentration ( P < 0.01 ).
Conclusions.
The results of present study showed that metformin and the hydroalcoholic extract of Teucrium polium prevent diabetes-induced memory deficits in rats.
Protection against brain tissues oxidative damage might have a role in the beneficial effects of the extract and metformin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mousavi, Seyed Mojtaba& Niazmand, Saeed& Hosseini, Mahmoud& Hassanzadeh, Zarha& Sadeghnia, Hamid Reza& Vafaee Bagheri, Farzaneh…[et al.]. 2015. Beneficial Effects of Teucrium polium and Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats. International Journal of Alzheimer's Disease،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1064463
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mousavi, Seyed Mojtaba…[et al.]. Beneficial Effects of Teucrium polium and Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats. International Journal of Alzheimer's Disease No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1064463
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mousavi, Seyed Mojtaba& Niazmand, Saeed& Hosseini, Mahmoud& Hassanzadeh, Zarha& Sadeghnia, Hamid Reza& Vafaee Bagheri, Farzaneh…[et al.]. Beneficial Effects of Teucrium polium and Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats. International Journal of Alzheimer's Disease. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1064463
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1064463
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر