Beneficial Effects of Teucrium polium and Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats
Joint Authors
Sadeghnia, Hamid Reza
Hassanzadeh, Zarha
Keshavarzi, Zakieh
Mousavi, Seyed Mojtaba
Niazmand, Saeed
Hosseini, Mahmoud
Vafaee Bagheri, Farzaneh
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
The effects of hydroalcoholic extract of Teucrium polium and metformin on diabetes-induced memory impairment and brain tissues oxidative damage were investigated.
Methods.
The rats were divided into: (1) Control, (2) Diabetic, (3) Diabetic-Extract 100 (Dia-Ext 100), (4) Diabetic-Extract 200 (Dia-Ext 200), (5) Diabetic-Extract 400 (Dia-Ext 400), and (6) Diabetic-Metformin (Dia-Met).
Groups 3–6 were treated by 100, 200, and 400 mg/kg of the extract or metformin, respectively, for 6 weeks (orally).
Results.
In passive avoidance test, the latency to enter the dark compartment in Diabetic group was lower than that of Control group ( P < 0.01 ).
In Dia-Ext 100, Dia-Ext 200, and Dia-Ext 400 and Metformin groups, the latencies were higher than those of Diabetic group ( P < 0.01 ).
Lipid peroxides levels (reported as malondialdehyde, MDA, concentration) in the brain of Diabetic group were higher than Control ( P < 0.001 ).
Treatment by all doses of the extract and metformin decreased the MDA concentration ( P < 0.01 ).
Conclusions.
The results of present study showed that metformin and the hydroalcoholic extract of Teucrium polium prevent diabetes-induced memory deficits in rats.
Protection against brain tissues oxidative damage might have a role in the beneficial effects of the extract and metformin.
American Psychological Association (APA)
Mousavi, Seyed Mojtaba& Niazmand, Saeed& Hosseini, Mahmoud& Hassanzadeh, Zarha& Sadeghnia, Hamid Reza& Vafaee Bagheri, Farzaneh…[et al.]. 2015. Beneficial Effects of Teucrium polium and Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats. International Journal of Alzheimer's Disease،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1064463
Modern Language Association (MLA)
Mousavi, Seyed Mojtaba…[et al.]. Beneficial Effects of Teucrium polium and Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats. International Journal of Alzheimer's Disease No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1064463
American Medical Association (AMA)
Mousavi, Seyed Mojtaba& Niazmand, Saeed& Hosseini, Mahmoud& Hassanzadeh, Zarha& Sadeghnia, Hamid Reza& Vafaee Bagheri, Farzaneh…[et al.]. Beneficial Effects of Teucrium polium and Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats. International Journal of Alzheimer's Disease. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1064463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1064463