Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics

المؤلفون المشاركون

Marchetti, Philippe
Guerreschi, Pierre
Mortier, Laurent
Kluza, Jerome

المصدر

International Journal of Cell Biology

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-17، 17ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-12-02

دولة النشر

مصر

عدد الصفحات

17

التخصصات الرئيسية

الأحياء

الملخص EN

Mitochondrial metabolism greatly influences cancer cell survival, invasion, metastasis, and resistance to many anticancer drugs.

Furthermore, molecular-targeted therapies (e.g., oncogenic kinase inhibitors) create a dependence of surviving cells on mitochondrial metabolism.

For these reasons, inhibition of mitochondrial metabolism represents promising therapeutic pathways in cancer.

This review provides an overview of mitochondrial metabolism in cancer and discusses the limitations of mitochondrial inhibition for cancer treatment.

Finally, we present preclinical evidence that mitochondrial inhibition could be associated with oncogenic “drivers” inhibitors, which may lead to innovative drug combinations for improving the efficacy of molecular-targeted therapy.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Marchetti, Philippe& Guerreschi, Pierre& Mortier, Laurent& Kluza, Jerome. 2015. Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics. International Journal of Cell Biology،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1065321

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Marchetti, Philippe…[et al.]. Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics. International Journal of Cell Biology No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1065321

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Marchetti, Philippe& Guerreschi, Pierre& Mortier, Laurent& Kluza, Jerome. Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics. International Journal of Cell Biology. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1065321

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1065321