Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics
Joint Authors
Marchetti, Philippe
Guerreschi, Pierre
Mortier, Laurent
Kluza, Jerome
Source
International Journal of Cell Biology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-02
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Mitochondrial metabolism greatly influences cancer cell survival, invasion, metastasis, and resistance to many anticancer drugs.
Furthermore, molecular-targeted therapies (e.g., oncogenic kinase inhibitors) create a dependence of surviving cells on mitochondrial metabolism.
For these reasons, inhibition of mitochondrial metabolism represents promising therapeutic pathways in cancer.
This review provides an overview of mitochondrial metabolism in cancer and discusses the limitations of mitochondrial inhibition for cancer treatment.
Finally, we present preclinical evidence that mitochondrial inhibition could be associated with oncogenic “drivers” inhibitors, which may lead to innovative drug combinations for improving the efficacy of molecular-targeted therapy.
American Psychological Association (APA)
Marchetti, Philippe& Guerreschi, Pierre& Mortier, Laurent& Kluza, Jerome. 2015. Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics. International Journal of Cell Biology،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1065321
Modern Language Association (MLA)
Marchetti, Philippe…[et al.]. Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics. International Journal of Cell Biology No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1065321
American Medical Association (AMA)
Marchetti, Philippe& Guerreschi, Pierre& Mortier, Laurent& Kluza, Jerome. Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics. International Journal of Cell Biology. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1065321
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065321