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Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases
المؤلفون المشاركون
Sherman, Larry S.
Matsumoto, Steven
Su, Weiping
Srivastava, Taasin
Back, Stephen A.
المصدر
International Journal of Cell Biology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-10
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The glycosaminoglycan hyaluronan (HA), a component of the extracellular matrix, has been implicated in regulating neural differentiation, survival, proliferation, migration, and cell signaling in the mammalian central nervous system (CNS).
HA is found throughout the CNS as a constituent of proteoglycans, especially within perineuronal nets that have been implicated in regulating neuronal activity.
HA is also found in the white matter where it is diffusely distributed around astrocytes and oligodendrocytes.
Insults to the CNS lead to long-term elevation of HA within damaged tissues, which is linked at least in part to increased transcription of HA synthases.
HA accumulation is often accompanied by elevated expression of at least some transmembrane HA receptors including CD44.
Hyaluronidases that digest high molecular weight HA into smaller fragments are also elevated following CNS insults and can generate HA digestion products that have unique biological activities.
A number of studies, for example, suggest that both the removal of high molecular weight HA and the accumulation of hyaluronidase-generated HA digestion products can impact CNS injuries through mechanisms that include the regulation of progenitor cell differentiation and proliferation.
These studies, reviewed here, suggest that targeting HA synthesis, catabolism, and signaling are all potential strategies to promote CNS repair.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sherman, Larry S.& Matsumoto, Steven& Su, Weiping& Srivastava, Taasin& Back, Stephen A.. 2015. Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases. International Journal of Cell Biology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065323
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sherman, Larry S.…[et al.]. Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases. International Journal of Cell Biology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1065323
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sherman, Larry S.& Matsumoto, Steven& Su, Weiping& Srivastava, Taasin& Back, Stephen A.. Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases. International Journal of Cell Biology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065323
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065323
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