Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases
Joint Authors
Sherman, Larry S.
Matsumoto, Steven
Su, Weiping
Srivastava, Taasin
Back, Stephen A.
Source
International Journal of Cell Biology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The glycosaminoglycan hyaluronan (HA), a component of the extracellular matrix, has been implicated in regulating neural differentiation, survival, proliferation, migration, and cell signaling in the mammalian central nervous system (CNS).
HA is found throughout the CNS as a constituent of proteoglycans, especially within perineuronal nets that have been implicated in regulating neuronal activity.
HA is also found in the white matter where it is diffusely distributed around astrocytes and oligodendrocytes.
Insults to the CNS lead to long-term elevation of HA within damaged tissues, which is linked at least in part to increased transcription of HA synthases.
HA accumulation is often accompanied by elevated expression of at least some transmembrane HA receptors including CD44.
Hyaluronidases that digest high molecular weight HA into smaller fragments are also elevated following CNS insults and can generate HA digestion products that have unique biological activities.
A number of studies, for example, suggest that both the removal of high molecular weight HA and the accumulation of hyaluronidase-generated HA digestion products can impact CNS injuries through mechanisms that include the regulation of progenitor cell differentiation and proliferation.
These studies, reviewed here, suggest that targeting HA synthesis, catabolism, and signaling are all potential strategies to promote CNS repair.
American Psychological Association (APA)
Sherman, Larry S.& Matsumoto, Steven& Su, Weiping& Srivastava, Taasin& Back, Stephen A.. 2015. Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases. International Journal of Cell Biology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065323
Modern Language Association (MLA)
Sherman, Larry S.…[et al.]. Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases. International Journal of Cell Biology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1065323
American Medical Association (AMA)
Sherman, Larry S.& Matsumoto, Steven& Su, Weiping& Srivastava, Taasin& Back, Stephen A.. Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases. International Journal of Cell Biology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065323
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065323